Objective:To study the treatment result of the unresectable advanced pancreatic cancer by radiotherapy. Methods: A total of 16 patients with unresectable advanced pancreatic cancer were treated by radiotherapy from March 1996 to December 2001. According to TNM staging system

there are 5 patients in stage II

6 in stage Ⅲ and 5 in stage Ⅳ. Karnofsky score were ranged from 30～70. Eight patients were treated by the conventional fractionation (1.8～2.0 cGy/f

5f/w)

and eight patients treated by non-conventional fractionation(1.2～1.8Gy/f

2～3f/d).The radiation dose was<40Gy for 3 cases

50～60Gy for 4 cases

61～70Gy for 6 cases

>70Gy for 3 cases. Results:The remission rate was 85.7 percent. The median survival course was 9.2 months(3～30months). 1-year survival rate was 31.25 percent. The pretreatment performance status and TNM stage were important prognostic factors. Both groups of Karnofsky score 60～70 and stageⅡ

Ⅲ showed a highly significantsurvival improvement when compared with groups of Karnofsky score 30～50and stage IV ( P <0.01). Conclusion:Radiotherapy is able to relieve symptoms

prolong survival time and improve life quality for patients with unresectable advanced cancer of pancreas.