高血压病人24小时血压变异性及依那普利的干预影响

刘勇; 杨涛

doi:10.13406/j.cnki.cyxb.2003.05.027

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高血压病人24小时血压变异性及依那普利的干预影响

更新时间：2024-01-17

- 高血压病人24小时血压变异性及依那普利的干预影响
- The study of 24-hours blood pressure variability and the intervention with enalapril in essential hypertensives
- 重庆医科大学学报 2003年第5期页码：636-638
- 作者机构：
  
  1. 四川省自贡市第二人民医院
  2. 四川省自贡市第二人民医院,四川,自贡,643000
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.05.027
  中图分类号： R544.1
- 纸质出版日期：2003，
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[1]刘勇,杨涛.高血压病人24小时血压变异性及依那普利的干预影响[J].重庆医科大学学报,2003(05):636-638.

LIU Yong, YANG Tao. The study of 24-hours blood pressure variability and the intervention with enalapril in essential hypertensives[J]. Journal of Chongqing Medical University, 2003,(5):636-638.
[1]刘勇,杨涛.高血压病人24小时血压变异性及依那普利的干预影响[J].重庆医科大学学报,2003(05):636-638. DOI： 10.13406/j.cnki.cyxb.2003.05.027.

LIU Yong, YANG Tao. The study of 24-hours blood pressure variability and the intervention with enalapril in essential hypertensives[J]. Journal of Chongqing Medical University, 2003,(5):636-638. DOI： 10.13406/j.cnki.cyxb.2003.05.027.

摘要

目的 :研究高血压患者 2 4小时血压变异性和依那普利的干预影响。方法 :4组对象中EHⅠ -Ⅱ期 90例

EHⅢ期4 2例

健康对照 6 0例

治疗组EHⅠ -Ⅱ期者 4 5例均进行 2 4小时动态血压监测并分析血压变异性（BPV）。结果 :两组高血压各时段SBPV及MAPV

EHⅢ期组的DBPV均大于对照组（P <0 .0 1或 0 .0 5 ） ;EHⅢ期组比EHⅠ -Ⅱ期者各时段SBPV、DBPV、MAPV均明显增大（P <0 .0 1或 0 .0 5 ） ;治疗组治疗前后各时段BPV无差异（P >0 .0 5 ）。结论 :高血压病人在血压平均值升高的同时

血压变异性（尤其是SBPV）也明显高于正常人

Ⅲ期高血压病人尤其显著 ;依那普利治疗 4周降压有效以后对血压变异性无显著性影响。

Abstract

Objective: To study 24-hour blood pressure variability (BPV) in essential hypertensives(EH) and to observe the effects of enalapril on BPV in the patients. Methods: BPV were evaluated in 132 EH patients (EH Ⅰ-Ⅱ group 90

EH Ⅲ group 42) using ambulatory blood pressure monitoring

and compared with 60 normal controls.45 EH Ⅰ-Ⅱ patients were treated with enalapril for 4 weeks by randomized single-blind study.The BPV were measured before and after treatment. Results: The SBPV and MAPV during 24-hour period

daytime or nighttime were significantly higher both EH Ⅰ-Ⅱ and EH Ⅲ than control group ( P <0.01 or 0.05)

but the DBPV was higher only in EH Ⅲ than control group( P <0.05).The SBPV

DBPV or MAPV during every interval were higher apparently in EH Ⅲ than EH Ⅰ-Ⅱ( P <0.05 or 0.01).There were no difference in BPV before and after treatment ( P >0.05).Conclusion:There was a significant increase in BPV(especially in SBPV) and in particular EH Ⅲ group than control group There was no effect in BPV with EH Ⅰ-Ⅱ group by enalapril treatment for 4 weeks.

关键词

原发性高血压动态血压监测血压变异性依那普利

Keywords

essential hypertensionABPMBlood pressure variabilityenalapril

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