Objective:To investigate the relationship between Helicobacter pylori(HP) and reflux esophagitis(RE). Methods: 1488 patients with esophagitis were diagnosed by gastroscope

and all of the patients were divided into five groups according to Tytagat. Biopsy specimens of each gastric mucosa were examined by rapid urease test assay.1600 patients with chronic gastritis and duodenal ulcer were also examined by rapid urease test assay. Results: The positive rates of Helicobacter pylori in reflux esophagitis

chronic gastritis and duodenal ulcer were63.04%

65.15% and 74.50%( P >0.05 and P <0.01) respectively. There was a negative correlation

the lower the positive rates

the heavier the reflux esophagitis ( P <0.01)

between the several levels of Helicobacter pylori and reflux esophagitis ( P <0.01) .Conclusion:1) There exists a dispute between Helicobacter pylori and episode procedure of reflux esophagitis. 2)Helicobacter pylori plays a protective role in episode procedure of reflux esophagitis.3)The eradication therapy for Helicobacter pylori should be taken more cautiously in the treatment of reflux esophagitis with continuing drug administration till its symptoms disappear.