Objective:To investigate the effect of tibolone on the symptoms of functional dyspepsia in menopausal women.Methods:143 menopausal patients with functional dyspepsia were divided into 3 groups at random.They were treated with tibolone or cisapride or both drugs respectively for 4 weeks.The scores of symptoms including epigastric pain and fullness

abdominal distention after meal

early satiety and belching were recorded before and after 2 or 4 weeks’ treatment.From the 3 guoups we drew out 20 patients at random.The gastric emptying was measured before and after 4 weeks’ treatment respectively.Results:The symptoms of epigastric pain and fullness

abdominal distention after meal were improved after 2

4 weeks’ treatment in three groups.Either tibolone or tibolone combined with cisapride remarkably relieved early satiety and belching

but no response was observed in the treatment of cisapride.The combination of tibolone and cisapride did not show better effect than tibolone treatment alone.The 30-min gastric emptying rates of all groups were significantly improved ( P <0.05) after 4 weeks’ treatment.No difference was observed between three groups ( P >0.05).Conclusion:Compared with cisapride

tibolone can increase gastric emptying and show better relief for the symptoms of functional dyspepsia in menopausal patients.