ZHANG Guirong, et al. The expressions of VEGF,CD44v6 and Ki67 in non-small cell lung carcinoma[J]. Journal of Chongqing Medical University, 2003,(4):473-476.
ZHANG Guirong, et al. The expressions of VEGF,CD44v6 and Ki67 in non-small cell lung carcinoma[J]. Journal of Chongqing Medical University, 2003,(4):473-476. DOI: 10.13406/j.cnki.cyxb.2003.04.020.
P <0 .0 5 ;VEGF、CD4 4v6及Ki6 7阳性的患者 3年生存率均明显低于阴性者。结论 :通过这 3个指标的检测
可以判断和预测NSCLC患者的预后及指导其临床治疗。
Abstract
Objective:To investigate the expressions of VEGF
CD44v6 and Ki67 in non-small cell lung carcinoma.Methods:The expressions of VEGF
CD44v6 and Ki67 in NSCLC tissue of 62 cases were studied by immunohistochemical staining.Results:All the positive rates were higher than matched normal lung tissues
P <0.01.Their expressions were related to clinical stages and the metastasis of lymph nodes.The expression rates of the three markers in NSCLC with the metastasis of lymph nodes were higher than those without metastasis
and the expressions of the three markers in Ⅲ-Ⅳ stages were higher than those in Ⅰ-Ⅱ stages
P <0.05.Survival rates of three years were lower among those patients with the positive expressions of these three markers than those with the negative expressions
P <0.05.Conclusion:The expression testing of the three markers may help in prediction of prognosis and clinical guidance for NSCLC patients.