Objective:To evaluate the efficacy and toxicity of the combined chemotherapy of ifosfamide plus vindesine and cisplatin in advanced non-small cell lung cancer.Methods:Fifty-two patients with advanced non-small cell lung cancer were treated by the combined chemotherapy of ifosfamide plus vindesine and cisplatin for two cycles:ifosfamide 1.5～2.0g/m 2 iv drip on day 1～5

mesna 400mg iv at 0

4

8 hours after using ifosfamide;vindesine 4mg iv on day 1

8;cisplation 60mg/m 2 iv drip on day 1.The response

toxicity and survival period were evaluated.Results:The total response rate was 44.2%.The response rate of patients in primary treatment was 47.1% and that of return cases was 38.9% ( P >0.05).The median duration of survival was eight months.The major toxicity was the inhibition of bone marrow

especially of leukocyte and platelet.Leukopenia and thrombocytopenia often appeared at day 8～12.Conlusion:The combined chemotherapy of ifosfamide plus vindesine and cisplatin is effective in advanced non-small cell lung cancer including the returm cases

and the toxicity is tolerable.If G-CSF is used as a complementary therapy

this regimen could be quite clinically valuable.