Objective:To study the effects of LAMS on modulation of HL-60 cell strain.Methods:MTT was used to determine the inhibiting action in the different concentration of LAMS on HL-60 cell strain.The attitude of Sub-G1 peak in DNA histogram was examined by FCM.NF-κB expression affected by LAMS was determined by using immunohistochemical stainings.Results:With the increase of LAMS concentration

the inhibiting effects on multiplication of HL-60 cells were decreased.After treatment of HL-60 cells with 0.75μg/ml LAMS for 6h?12h?24h

the expression of P65 was the most significant at 12h

while the expression of IKbα was the most significant at 6h.The exptession of NF-κB reduced in LAMS group without time-dependent pattern.Conclusion:LAMS can induce HL-60 cells apoptosis.LAMS can modulate the expression of NF-κB.It also suggested that LAMS had an influence at molecular level.