胃癌组织COX-2的表达及其与细胞增殖和凋亡的关系

高青; 刘兴; 王丕龙

doi:10.13406/j.cnki.cyxb.2003.03.007

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胃癌组织COX-2的表达及其与细胞增殖和凋亡的关系

更新时间：2024-01-17

- 胃癌组织COX-2的表达及其与细胞增殖和凋亡的关系
- The expression of COX-2 and its relationship to the apoptosis and proliferation in gastric cancer
- 重庆医科大学学报 2003年第3期页码：276-278
- 作者机构：
  
  1. 重庆医科大学临床学院消化内科
  2. 重庆急救中心中心实验室
  3. 重庆医科大学临床学院消化内科,重庆,400016
  4. ,重庆,400014
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.03.007
  中图分类号： R735.2
- 纸质出版日期：2003，
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[1]高青,刘兴,王丕龙.胃癌组织COX-2的表达及其与细胞增殖和凋亡的关系[J].重庆医科大学学报,2003(03):276-278+315.

GAO Qing, et al. The expression of COX-2 and its relationship to the apoptosis and proliferation in gastric cancer[J]. Journal of Chongqing Medical University, 2003,(3):276-278.
[1]高青,刘兴,王丕龙.胃癌组织COX-2的表达及其与细胞增殖和凋亡的关系[J].重庆医科大学学报,2003(03):276-278+315. DOI： 10.13406/j.cnki.cyxb.2003.03.007.

GAO Qing, et al. The expression of COX-2 and its relationship to the apoptosis and proliferation in gastric cancer[J]. Journal of Chongqing Medical University, 2003,(3):276-278. DOI： 10.13406/j.cnki.cyxb.2003.03.007.

摘要

目的 :探讨环氧化酶 - 2 （cyclooxygenase - 2

COX - 2 ）在胃癌组织中的表达与癌细胞增殖和凋亡的关系。方法 :采用免疫组织化学的方法检测 4 3例胃癌患者COX - 2和增殖细胞核抗原（PCNA）的表达

用TUNEL法检测原位细胞凋亡的情况。分别计算细胞增殖指数（MI）和凋亡指数（AI）。结果 :胃癌组织COX - 2表达的阳性率为 6 0 .4 7%

明显高于对照组（P <0 .0 1）。COX - 2的高表达与胃癌淋巴结的转移和临床分期有关

与肿瘤大小、浸润深度、分化程度均无关。COX - 2阳性胃癌组中MI高于COX - 2阴性胃癌组

而AI却低于COX - 2阴性胃癌组（P均 <0 .0 1）。结论 :COX - 2的过度表达可促进胃癌细胞增殖、抑制细胞凋亡

在胃癌的发生、发展过程中起着重要的作用。

Abstract

Objective:To investigate the expression level of COX-2 and their effects on cell proliferation activity and apoptosis degree in gastric cancinoma.Methods:The expression of COX-2

proliferating cell nuclear antigen(PCNA) and apoptosis in 43 cases of gastric cancer were studied by immunohistochemistry and TUNEL methods

and the proliferation index (PI) and apoptotic index(AI) were defined respectively.Results:The positive expression rate of COX-2 was 60.47% in gastric carcinoma tissue.It was significantly higher than that in the control group.Overexpression of COX-2 in gastric carcinoma was related to its lymph node metastasis and clinical stage

but it did not correlate with the size of tumor

depth of the invasion and the differentiation degree( P >0.05).In the group with COX-2 positive expression AI was higher than that of the group with COX-2 negative expression

whereas AI was higher in the latter group than in the former ( P <0.01).Conclusion:The expression level of COX-2 may have a close correlation with cell proliferation and apoptosis and they may participate in oncogenesis and progression of gastric carcinoma.

关键词

胃癌环氧化酶-2细胞增殖细胞凋亡

Keywords

Cyclooxygenase-2Gastric carcinomaProliferating cell nuclear antigen(PCNA)apoptosis

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