Objective: To study the changes and effects of NPY

ET and CGRP in plasma on the patients of Qi-deficiency and Blood-stasis syndrome (QDBS). Methods: The levels of NPY

ET and CGRP in plasma were measured by radioimmunoassay (RIA) in 58 patients with QDBS and 15 healthy elders and 23 healthy youngers. Results: The levels of NPY and ET in plasma in the patients with QDBS were significantly higher than in the healthy elders and healthy youngers ( P <0.01).At the same time

the level of CGRP in plasma in the patients with QDBS were significantly lower than in the healthy elders and healthy youngers ( P <0.01).There was no significant change among the healthy elders and healthy youngers on the levels of NPY

ET and CGRP in plasma ( P>0.01).The plasma levels of NPY had no correlation with ET and CGRP in all the three groups (P >0.01).There was significant positive correlation between ET and CGRP in plasma in the healthy elders and healthy youngers (P <0.01).There was significant negative relationship between ET and CGRP in plasma in the QDBS patients ( P <0.01). Conclusion: The increase of NPY

ET and the decrease of CGRP in plasma can serve as one of diagnostic standards for QDBS.It may reflect the degree of QDBS.The change of NPY

ET and CGRP in plasma can be used as the standard on the development of QDBS and the effect of QDBS remedy.