Objective: To inspect the change of gallbladder contraction in the menopause patients with functional dyspepsia (MPFD) and investigate the effect of tibolone

a compound with the effects of estrogen

progestogen and androgen

on the gallbladder emptying of MPFD. Methods: 15 young healthy volunteers were treated with cisapride 5mg three times a day.91 MPFD were divided into 3 groups at random.They were treated with tibolone 2.5mg once a day;cisapride 5mg three times a day and combination of both drugs respectively.The gallbladder emptying in three groups’ patients was measured before and after 4 weeks’ treatment. Results: Postprandial gallbladder volume in the volunteers was significantly reduced and gallbladder ejection fraction was enhanced 19.7% after taking cisapride ( P <0.05).Compared with young healthy volunteers

preprandial gallbladder ejection fraction of MPED was not significantly different.However

no response for cisapride was observed in postprandial gallbladder ejection fraction of MPED.Postprandial gallbladder ejection fraction of MPFD was remarkably enhanced 11.2% ( P <0.05) by the combination of tibolone and cisapride. Conclusion: The down-reservation of gallbladder ejection in MPFD may contribute to their symptoms.Postprandial gallbladder ejection fraction of MPFD could be improved by the combination of tibolone and cisapride.