Objective:To investigate the clinical value of rapid supraclavicular subclavian catheterization during cardiopulmonary resuscitation. Methods:218 patients with cardiac arrest were randomly divided into central and peripheral intravenous groups for drug administration. We compared the effect of two pathways for drug administration during CPR. Results:There were no significant differi-ence in time of catheterization and success rate of catheterizaiton between the two groups. The RSC time in group C was shorter and early success rate was significantly higher than that of group P. Conclusion : Supraclavicular approach to subclavian catheterization for drug administration increased the success rate of CPR at an early stage and proves beneficial to cerebral resuscitation. It will provide the best pathway for drug administration during CPR.