Objective:To investigate the dynamical effects and mechanisms of Cordyceps sinensis(CS) on hepatic glycogen level in CC14 induced hepatic fibrosis in rats. Methods: Rats were randomly allocated into a normal group

a model group and a CS group. The latter two groups were administered with CC14 solution to induce hepatic fibrosis. The CS group was also treated with CS 10 days after the beginning of CC14 administration. Rats in the normal group were sacrificed at the beginning of the experiment

while the other two groups were sacrificed randomly at the end of the third

the sixth and the ninth week. Blood and tissue specimens were taken. Biochemical assays were used to determine the change of the serum ALT

ALB level

and radioimmunological aasays were used to determine the change of the serum HA level. The hepatic glycogen levels were detected by anthrone. Results : There were no significant differences of the serum level of ALT

ALB

HA between the CS group and the model group at the third and the sixth week( P > 0. 05) . The serum level of ALT

HA in the CS group was lower than that in the model group at the ninth week(P<0.05)

but the serum level of ALB in the CS group was higher than that in the model group at the ninth week( P < 0. 05). The hepatic glycogen levels in the CS group and the model group were lower than that of the normal group(P<0. 01). There were no differences in the hepatic glycogen level between the CS group and the model group( P > 0.05). There were no time - dynamical change in the hepatic glycogen levels among all the rats at the third

the sixth and the ninth week(P>0. 05). Conclusion :Cordyceps sinensis can inhibit the hepatic fibrosis

and at the same time

doesn’t improve the hepatic glycogen synthesis.