胃癌患者胃液血清中CA72-4、CA19-9和CEA联合检测的临床价值探讨

成军; 王严庆

doi:10.13406/j.cnki.cyxb.2003.01.006

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胃癌患者胃液血清中CA72-4、CA19-9和CEA联合检测的临床价值探讨

更新时间：2024-01-17

- 胃癌患者胃液血清中CA72-4、CA19-9和CEA联合检测的临床价值探讨
- Combining testing gastric juice and serum levels of CA72 - 4、A19 - 9 and CEA for the clinical value of gastric cancer
- 重庆医科大学学报 2003年第1期页码：17-20
- 作者机构：
  
  1. 重庆医科大学临床学院普外科
  2. 重庆医科大学临床学院普外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.01.006
  中图分类号： R735.2
- 纸质出版日期：2003，
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[1]成军,王严庆.胃癌患者胃液血清中CA72-4、CA19-9和CEA联合检测的临床价值探讨[J].重庆医科大学学报,2003(01):17-20.

CHENG Jun, et al. Combining testing gastric juice and serum levels of CA72 - 4、A19 - 9 and CEA for the clinical value of gastric cancer[J]. Journal of Chongqing Medical University, 2003,(1):17-20.
[1]成军,王严庆.胃癌患者胃液血清中CA72-4、CA19-9和CEA联合检测的临床价值探讨[J].重庆医科大学学报,2003(01):17-20. DOI： 10.13406/j.cnki.cyxb.2003.01.006.

CHENG Jun, et al. Combining testing gastric juice and serum levels of CA72 - 4、A19 - 9 and CEA for the clinical value of gastric cancer[J]. Journal of Chongqing Medical University, 2003,(1):17-20. DOI： 10.13406/j.cnki.cyxb.2003.01.006.

摘要

目的:探讨胃液血清CA72-4、CA19-9和CEA联合检测对胃癌的诊断价值。方法:采用IRMA法测定32例各期胃癌和20例良性胃病患者胃液和血清中CA72-4、CA19-9和CEA的含量。结果:胃癌组胃液及血清CA72-4、CA19-9和CEA定值平均水平和灵敏度显著高于良性胃病组（P<0.01）;胃癌组胃液CA72-4、CA19-9和CEA测定值平均水平显著高于其血清水平（P<0.01）;胃液CA19-9+血清CA19-9+血清CA72-4联合检测效果最高;晚期胃癌患者胃液和血清CA72-4、CA19-9水平和灵敏度高于早期病例（P<0.05）。结论:选择适当的血清、胃液肿瘤标志物联合检测不仅可能提高胃癌的早期诊断率

还能提示肿瘤的扩散和转移

以及预后判断

都有一定的临床价值。

Abstract

Objective:To explore the clinical value of gastric cancer by combined testing of the gastric juice and serum levels of CA72 - 4

CA19 - 9 and CEA. Methods :The gastric juice and serum levels of CA72 - 4

CA19 - 9 and CEA in 32 cases of all stages of gastric cancer and 20 cases of benign gastric disorders were determined preoperatively using IRMA method. Results: The results showed that the gastric juice

serum levels and the sensitivity rates of CA72 - 4

CA19 ~ 9 and CEA were significantly higher ( P < 0.01)) in the gastric cancer group than in the benigh gastric disorders group. The gastric juice levels of CA72 - 4

CA19 - 9 and CEA were also higher than the serum levels in the gastric cancer group. The results showed that the sensitivity rate of combining assaying gastric juice CA19 - 9

serum CA19-9 and serum CA72 - 4 was 78. 13 % . The gastric juice and serum levels of CA72 - 4

CA19 - 9 in early stage ( Ⅰ

Ⅱ ) of gastric cancer were higher than those in progressive and late stage ( Ⅲ

Ⅳ ). Conclusion : The reasonable preopera-tive combining test might be of high value for early diagnosis

predicting the diffusion and metastasis

improving the therapeutic effect and prognosis for gastric cancer

关键词

固相免疫放射分析法胃癌CA72-4CA19-9CEA

Keywords

Immunoradiometric analysis (IRMA)gastric cancerCA72 - 4CAl9 - 9CEAD

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