膀胱移行细胞癌尿脱落细胞VEGF表达的研究

吴小候; 罗春丽; 蔡晓钟

doi:10.13406/j.cnki.cyxb.2002.01.014

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膀胱移行细胞癌尿脱落细胞VEGF表达的研究

更新时间：2024-01-17

- 膀胱移行细胞癌尿脱落细胞VEGF表达的研究
- An study of expression of vascular endothelial growth factor in urinary cytology in transitional cell bladder carcinoma
- 重庆医科大学学报 2002年第1期页码：45-47
- 作者机构：
  
  1. 重庆医科大学临床学院泌尿外科
  2. 重庆医科大学检验系,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2002.01.014
  中图分类号： R737.14
- 纸质出版日期：2002，
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[1]吴小候,罗春丽,蔡晓钟.膀胱移行细胞癌尿脱落细胞VEGF表达的研究[J].重庆医科大学学报,2002(01):45-47.

WU Xiaohou, et al. An study of expression of vascular endothelial growth factor in urinary cytology in transitional cell bladder carcinoma[J]. Journal of Chongqing Medical University, 2002,(1):45-47.
[1]吴小候,罗春丽,蔡晓钟.膀胱移行细胞癌尿脱落细胞VEGF表达的研究[J].重庆医科大学学报,2002(01):45-47. DOI： 10.13406/j.cnki.cyxb.2002.01.014.

WU Xiaohou, et al. An study of expression of vascular endothelial growth factor in urinary cytology in transitional cell bladder carcinoma[J]. Journal of Chongqing Medical University, 2002,(1):45-47. DOI： 10.13406/j.cnki.cyxb.2002.01.014.

摘要

目的：研究尿脱落细胞ＶＥＧＦ表达与膀胱癌的关系，探讨其作为膀胱肿瘤诊断标记物的临床意义。方法：应用免疫组化技术检测４０例膀胱癌患者和２０例非肿瘤患者尿脱落细胞ＶＥＧＦ的表达。结果：ＶＥＧＦ在非肿瘤组尿脱落细胞无表达，而在肿瘤组尿脱落细胞表达率为４０％，联合常规ＨＥ染色检测可提高肿瘤检出率达８６．２％。复发组膀胱癌尿脱落细胞ＶＥＧＦ表达率７０％，明显高于初发组的３０％（Ｐ＜０．０５）。ＶＥＧＦ在膀胱癌的表达率与肿瘤分期有相关性，而与肿瘤分级程度无相关性。结论：检测尿脱落细胞ＶＥＧＦ表达，可作为膀胱肿瘤诊断、监测复发的良好指标，可提高尿脱落细胞检测膀胱癌的阳性率。

Abstract

Objective:To evaluate expression of vascular endothelial growth factor (VEGF) in urinary cytology and possibility of VEGF as a marker for diagnosis of bladder cancer. Methods: The expression of VEGF in urinary cytology by immunohistochemical staining was examined in 40 cases of transitional cell bladder carcinoma and 20 subjects with normal urothelium.Results: The positive staining of VEGF in 40 patients with bladder cancer were 40%

the expression of VEGF was negative in all controls. It was revealed that the expression of VEGF was significantly higher in recurrent lesions(70%) than in the primary cases(30%). There was also a significant difference in the expression of VEGF between those with infiltrative lesions and the superficial ones. Conclusion: The findings suggest that VEGF in urinary cytology can be used as a valuable marker for diagnosis of bladder cancer.

关键词

尿脱落细胞血管内皮生长因子膀胱肿瘤

Keywords

Urinary cytologyVascular endothelial growth factor (VEGF)Bladder neoplasms

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