果糖二磷酸钠镁对心肌缺血大鼠血流动力学的影响

朱深银; 周远大; 何海霞; 王驰

doi:10.13406/j.cnki.cyxb.2001.04.012

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果糖二磷酸钠镁对心肌缺血大鼠血流动力学的影响

更新时间：2024-01-17

- 果糖二磷酸钠镁对心肌缺血大鼠血流动力学的影响
- Effects of sodium magnesium fructose diphosphate on hemodynamics in myocardial ischemia rats
- 重庆医科大学学报 2001年第4期页码：397-401
- 作者机构：
  
  1. 重庆医科大学临床学院临床药理研究室
  2. 重庆医科大学基础医学院化学教研室,重庆,400016
- 作者简介：
- 基金信息：
  
  重庆市卫生局科学基金（97—4）
- DOI：10.13406/j.cnki.cyxb.2001.04.012
  中图分类号： R965
- 纸质出版日期：2001，
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[1]朱深银,周远大,何海霞,王驰.果糖二磷酸钠镁对心肌缺血大鼠血流动力学的影响[J].重庆医科大学学报,2001(04):397-401.

ZHTJ Shen - yin, et al. Effects of sodium magnesium fructose diphosphate on hemodynamics in myocardial ischemia rats[J]. Journal of Chongqing Medical University, 2001,(4):397-401.
[1]朱深银,周远大,何海霞,王驰.果糖二磷酸钠镁对心肌缺血大鼠血流动力学的影响[J].重庆医科大学学报,2001(04):397-401. DOI： 10.13406/j.cnki.cyxb.2001.04.012.

ZHTJ Shen - yin, et al. Effects of sodium magnesium fructose diphosphate on hemodynamics in myocardial ischemia rats[J]. Journal of Chongqing Medical University, 2001,(4):397-401. DOI： 10.13406/j.cnki.cyxb.2001.04.012.

摘要

目的：观察果糖二磷酸钠镁（ＦＤＰＭ）对心肌缺血大鼠血流动力学作用。方法：采用垂体后叶素诱发大鼠急性心肌缺血，经ＭＰＡ－Ｖ，型多道生物信号分析系统监测血流动力学变化。结果：（１）给垂体后叶素后，ＭＡＰ、ＬＶＥＤＰ升高，ＩＴ延长，ＨＲ、＋ｄＰ／ｄｔｍａｘ、－ｄＰ／ｄｔｍａｘ、Ｖｃｅ－５ｋＰａ降低；（２）ＦＤＰＭ升高降低的＋ｄＰ／ｄｔｍａｘ、－ｄＰ／ｄｔｍａｘ及Ｖｃｅ－５ｋＰａ，降低升高的ＬＶＥＤＰ，同时降低ＭＡＰ和减慢ＨＲ；该作用具有剂量依赖性。结论：ＦＤＰＭ能改善心肌缺血大鼠的血流动力学。

Abstract

Objective To investigate the effect of sodium magnesium frutose diphosphate (FDPM) on hemodynarntcs in myocardial ischernia rats. l’tiethods : Acute myocardial ischemia model were induced by pituitrin in rats

and then hemodynamic variables were monitored with multichannel biological signal analytical system. Results: After administation of pituitrin MAP and LVEDP were increased

IT was prolonged

HR. + dP/dtmax

- dP/ dtmax

and Vce - 5kPa were simultaneously decreased. Alter i. v. bolus injection of FDPM

+ dP/dtmax

- dP/ dtmax

Vce - 5kPa and Vpm were increased in the rats suffering from acute myocardial ischemia induced by pituitrin; MAP and L\IDP were decreased; IT was shortened

and meanwhile HR was lowered. The effects mentioned above were dose - dependent. Conclusion : FDPM can improve hemodynamics of myocardial ischemia rats induced by pituitrin.

关键词

果糖二磷酸钠镁血流动力学心肌缺血

Keywords

Sodium magnesium fructose diphosphateHemodnamicsMyocardial Ischemia

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