阿霉素对重组人肿瘤坏死因子介导的结肠癌细胞（COLO205）细胞毒增敏作用

骆云鹏; LIU Rosa; SALMON Sydney E

doi:10.13406/j.cnki.cyxb.2001.04.011

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阿霉素对重组人肿瘤坏死因子介导的结肠癌细胞（COLO205）细胞毒增敏作用

更新时间：2024-01-17

- 阿霉素对重组人肿瘤坏死因子介导的结肠癌细胞（COLO205）细胞毒增敏作用
- sitization of colon cancer cells (COLO205) treated with Doxorubicin to rHuTNF - mediated cytotoxicity
- 重庆医科大学学报 2001年第4期页码：393-396
- 作者机构：
  
  1. 重庆医科大学病理生理教研室
  2. HTCA Laharatory Cancer　Center
  3. Lniversity　 of　Arizona
  5. Tucson,85724
  6. ,USA
- 作者简介：
- 基金信息：
  
  This work is supported by grants CA - 21893, CA -l7094 and contract NOI - CNI - 57662 from NIH.
- DOI：10.13406/j.cnki.cyxb.2001.04.011
  中图分类号： R735.35
- 纸质出版日期：2001，
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[1]骆云鹏,LIU Rosa,SALMON Sydney E.阿霉素对重组人肿瘤坏死因子介导的结肠癌细胞(COLO205)细胞毒增敏作用[J].重庆医科大学学报,2001(04):393-396.

LUO Yun - peng, et al. sitization of colon cancer cells (COLO205) treated with Doxorubicin to rHuTNF - mediated cytotoxicity[J]. Journal of Chongqing Medical University, 2001,(4):393-396.
[1]骆云鹏,LIU Rosa,SALMON Sydney E.阿霉素对重组人肿瘤坏死因子介导的结肠癌细胞(COLO205)细胞毒增敏作用[J].重庆医科大学学报,2001(04):393-396. DOI： 10.13406/j.cnki.cyxb.2001.04.011.

LUO Yun - peng, et al. sitization of colon cancer cells (COLO205) treated with Doxorubicin to rHuTNF - mediated cytotoxicity[J]. Journal of Chongqing Medical University, 2001,(4):393-396. DOI： 10.13406/j.cnki.cyxb.2001.04.011.

摘要

目的：评价阿霉素和ｒＨｕＴＮＦ抗人结肠癌细胞株的序贯作用。方法：采用克隆生成试验（Ｈａｍｂｕｒｇｅｒ－Ｓａｌｍｏｎ法），研究ＤＯＸ和ｒＨｕＴＮＦ序贯作用于ＣＯＬＯ２０５细胞株后的抗增殖效果。结果：对结肠癌细胞系ＣＯＬＯ２０５，存在ＤＯＸ－ｒＨｕＴＮＦ序贯抗增殖作用；多数联合给药情况下出现相加／协同作用。结论：ＤＯＸ存在时，ＴＮＦ的抗瘤作用增强，从而支持ＤＯＸ可干扰细胞保护机制以使瘤细胞对ＴＮＦ细胞毒作用更为敏感的理论。

Abstract

Objective: To evaluate the sequential action of rHuTNF and doxorubicin (DOX) against hurnan colon cancer cell line (COLO205 ). Method: With clonogenic aSSa(Hamburger -- Salmon methed)

the sequen- tial roles of rHuTNF and DOX on COLO205 were investigated. The dose -- effect relationships of each drug alone and in combination were analyzed by examining the survival fraction of the drug combination. Results: The ac- tion of DOX and rHuTNF against proliferation was found to be schedule -- dependent in colon cancer line CO- LO205;marked synergistic effects were observed in most instances of trearment

when DOX was administered prior to and not following rHuTNF. Chnclusion: The anti -- tumor effect of TNF can be enhanced in the presece of DOX

suggestion that the addition of DOX may interfere with the cellular protective mechanism

causing the tumor cells to become rae susceptible to the cytotoxic action of TNF.

关键词

肿瘤坏死因子阿霉素COLO205克隆生成试验药物序贯作用

Keywords

TNFDoxorubicinCOLO205Clongenic assaySequential ro1es of drugs

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