慢性肾功能不全患者尿中NAG、RBP和FDP检测及意义

杜晓刚; 甘华; 谯林; 刘渝梅

doi:10.13406/j.cnki.cyxb.2001.03.019

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慢性肾功能不全患者尿中NAG、RBP和FDP检测及意义

更新时间：2024-01-17

- 慢性肾功能不全患者尿中NAG、RBP和FDP检测及意义
- The analysis of the relation between urinary NAG、RBP and urinary FDP in glomerulonephritis patients with chronic renal insufficiency
- 重庆医科大学学报 2001年第3期页码：285-287
- 作者机构：
  
  1. 重庆医科大学临床学院肾内科
  2. 重庆医科大学临床学院肾内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2001.03.019
  中图分类号： R692.5
- 纸质出版日期：2001，
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[1]杜晓刚,甘华,谯林,刘渝梅.慢性肾功能不全患者尿中NAG、RBP和FDP检测及意义[J].重庆医科大学学报,2001(03):285-287.

DU Xiao - gang, et al. The analysis of the relation between urinary NAG、RBP and urinary FDP in glomerulonephritis patients with chronic renal insufficiency[J]. Journal of Chongqing Medical University, 2001,(3):285-287.
[1]杜晓刚,甘华,谯林,刘渝梅.慢性肾功能不全患者尿中NAG、RBP和FDP检测及意义[J].重庆医科大学学报,2001(03):285-287. DOI： 10.13406/j.cnki.cyxb.2001.03.019.

DU Xiao - gang, et al. The analysis of the relation between urinary NAG、RBP and urinary FDP in glomerulonephritis patients with chronic renal insufficiency[J]. Journal of Chongqing Medical University, 2001,(3):285-287. DOI： 10.13406/j.cnki.cyxb.2001.03.019.

摘要

目的：探讨慢性肾功能不全（ＣＲＩ）患者尿Ｎ－乙酰－β－Ｄ－氨基葡萄糖苷酶（ＮＡＧ）、视黄醇结合蛋白（ＲＢＰ）与纤维蛋白降解产物（ＦＤＰ）变化及其意义。方法：应用比色法、酶联免疫法及乳胶凝集法分别检测２５例慢性肾小球肾炎ＣＲＩ患者和２８例健康对照组尿ＮＡＧ、ＲＢＰ及ＦＤＰ水平。结果：ＣＲＩ患者尿ＲＢＰ含量、ＮＡＧ活性明显增高（Ｐ＜０．０１），且在尿ＦＤＰ阳性组及伴高血压的ＣＲＩ患者尿ＲＢＰ及ＮＡＧ升高更明显（Ｐ＜０．０５）。结论：ＣＲＩ患者残存肾单位肾小球内凝血以及伴有的高血压可能是其小管－间质损害加重的重要因素。

Abstract

Objective: To analyse the relation and the significance between urinary N - acetyl- beta- d - glu- cosaminidase (NAG) retinol - binding protein (RBP) and products of fibrin degradation (FDP) in glomeru- lonephritis patients with chronic renal insufficiency (CRI). Methods: We measured the levels of urinary NAG、 RBP and FDP of the 25 cases of patients with CRI by use of colorimetry ELISA and latex coagulation test. Re- sults : The levels of urinary NAG RBP in patients with CRI were significantly higher than those in the control group

the levels of urinary NAG RBP in the positive group of urinary FDP were higher than those in the nega- tive group

and the levels in CRI patients with hypertension were higher than the levels in those without hyper- tension. Conclusion: The procedure of the coagulation in residual nephron and hypertension may be important factors in aggravating the tubulointerstitial lesion in glomerulonephritis patients with CRI.

关键词

慢性肾功能不全州-乙酰-β-D-氨基葡萄糖苷酶视黄醇结合蛋白纤维蛋白降解产物

Keywords

Chronic renal insufficiencyN - acetyl-beta- d - glucosaminidaseRetinol- binding proteinProducts of fibrin degradation

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