2型糖尿病患者血浆TXA2和PGI2失衡及PLA2活性变化

万青; 邓华聪; 邱鸿鑫; 杨刚毅; 祝继华; 唐晓琼

doi:10.13406/j.cnki.cyxb.2001.03.011

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2型糖尿病患者血浆TXA₂和PGI₂失衡及PLA₂活性变化

更新时间：2024-01-17

- 2型糖尿病患者血浆TXA₂和PGI₂失衡及PLA₂活性变化
- The unbalance of TXA₂ and PGI₂ and the change of PLA₂ activity in type 2 diabetes mellitus patients
- 重庆医科大学学报 2001年第3期页码：257-260
- 作者机构：
  
  1. 重庆医科大学临床学院普内科
  2. 重庆医科大学临床学院普内科,重庆,400016
- 作者简介：
- 基金信息：
  
  国家自然科学基金资助（39570344）
- DOI：10.13406/j.cnki.cyxb.2001.03.011
  中图分类号： R587.1
- 纸质出版日期：2001，
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[1]万青,邓华聪,邱鸿鑫,杨刚毅,祝继华,唐晓琼.2型糖尿病患者血浆TXA_2和PGI_2失衡及PLA_2活性变化[J].重庆医科大学学报,2001(03):257-260.

WAN Qing, et al. The unbalance of TXA₂ and PGI₂ and the change of PLA₂ activity in type 2 diabetes mellitus patients[J]. Journal of Chongqing Medical University, 2001,(3):257-260.
[1]万青,邓华聪,邱鸿鑫,杨刚毅,祝继华,唐晓琼.2型糖尿病患者血浆TXA_2和PGI_2失衡及PLA_2活性变化[J].重庆医科大学学报,2001(03):257-260. DOI： 10.13406/j.cnki.cyxb.2001.03.011.

WAN Qing, et al. The unbalance of TXA₂ and PGI₂ and the change of PLA₂ activity in type 2 diabetes mellitus patients[J]. Journal of Chongqing Medical University, 2001,(3):257-260. DOI： 10.13406/j.cnki.cyxb.2001.03.011.

摘要

目的：探讨２型糖尿病（ＤＭ）患者血栓素Ａ２（ＴＸＡ２）和前列环素（ＰＧＩ２）失衡及ＰＬＡ活性变化。方法：以放免法测定血栓素Ｂ２和６－酮－前列腺素含量，以改良Ｚｉｅｖｅ法测定血浆ＰＬＡ２活性，同时观察空腹血糖（ＦＢＧ）、空腹胰岛素（ＦＩＮＳ）、甘油三酯（ＴＧ）等的变化。结果：①２型ＤＭ患者存在ＴＸＡ２和ＰＧＩ２合成异常，且Ⅱ组（有微血管病变组）较Ⅰ组（无微血管病变组）更为严重；②２型ＤＭ患者组血浆ＰＬＡ２显著低于正常对照组，但 Ⅰ组与Ⅱ组之间无显著差异；③２型ＤＭ患者组ＴＸＢ２与ＦＢＧ、ＴＧ显著正相关，６－Ｋ—ＰＧＦ１８ＦＩＮＳ显著负相关，ＴＸＢ２与６－Ｋ－ＰＧＦ１ａ均与血浆ＰＬＡ２无显著相关性。结论：①ＴＸＡ２和ＰＧＩ２失衡在２型糖尿病及其微血管病变的发生发展中起重要作用；③血浆分泌型ＰＬＡ２活性变化与２型糖尿病密切有关，但在糖尿病患者ＴＸＡ２和ＰＧＩ２失衡及微血管病变中可能不起直接作用；③糖脂代谢紊乱以及高胰岛素血症在ＴＸＡ和ＰＧＩ２失衡及ＤＭ微血管病变中起重要作用。

Abstract

Objective.To study the unbalance of thromboxane A2(TXA2) and prostacyclin (PGIa) and the change of PLA2 activity in type 2 diabetes mellitus (DM) patients. Methods-.The levels of plasma thrombox- aneB2 and 6 - K - PGF1a were assayed by radioimmunoassay and the PLA2 activity was determined by the im- proved Zieve method

with simultaneous determination of fasting blood glucose (FBG) .fasting insulin (FINS)

triglyceride (TG) and cholesterol (TC)

etc. Results : ①The unbalance of TXA2 and PGI2 existed in type 2 DM patients

and it was worse in group Ⅱ (with microvasculopthy) than in group Ⅰ (without microvasculopathy); ② In type 2 DM patient group plasma PLA2 activity was significantly lower than that in normal controls

but had no marked difference between the group I and the group Ⅱ ; ③ In type 2 DM patient group

TXBz was positive- ly correlated with FBG.TG (P<0.05)

6-K-PGFla was negatively correlated with FINS (P<0.05)

TXB2 and 6-K-PGF1a had no significant correlation with plasma PLA2. Conclusion: (DThe unbalance of TXA2 and PGI2 plays an important role in the onset and the development of tape 2 DM and microvasculopathy; ② The change of plasma secrete PLA2 activity has a close relationship with type 2 diabetes mellitus

but may not be the direct cause of the unbalance of plasma TXA2 and PGI2 and microvasculopathy; ㏕he disorder of glucose and lipid metabolism and hyperinsulinemia play an important role in the unbalance of TXA2 and PGI2 and microvas- culopathy.

关键词

血栓素A2前列环素磷脂酶A22型糖尿病

Keywords

thromboxane A2ProstacyclinPhospholipase A2type 2 diabetes mellitus

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