：Objective To explore the possibility of repair of the extensive bile duct injuries with expanded polytetrafluoroethylene (ePTFE). Methods A total of 24 local healthy hybrid dogs were employed to establish bile duct injury models by means of partial removal of bile duct

excision of a segmental duct. The bile duct defects were patched with ePTFE mesh

segmental loss replaced by ePTFE tube. The animals performance status and changes in the color of skin

sclera and stool were evaluated. Cholangiography was used to define the patency of bile duct with/without stricture and obstruction formation. Anastomotic tissue of bile ducts and liver tissues were taken at different time for microscopic and ultrastructural examination to determine foreign reactions to grafts

the healing process of bile duct and morphological changes in the liver. Results It was demonstrated that repair of the bile duct defects with ePTFE patch covered by epithelium had a high patency rate of 75%(9/12) and pathological damages were not found in the liver. The patency rate of segmental replacement of ducts was merely 40%(4/10)

to some extent

accompanying damages in the liver. Conclusion The study showed that repair of bile duct defects with ePTFE patch had better results than segmental replacement（unilaterally

Ｐ<0.05）.