： Objective To explore the cardioprotective role and mechanism of brief ischemia in remote organs. Methods 48 Wistar rats were randomly divided into 6 groups. PKCαand PKCδwere measured by immunohistochemistry method. Results 15 minutes occlusion of the mesensteric artery (MAO) and femotall artery (FAO) can protect against myocardial infarction as effectively as coronary artery occlusion (CAO). PKCα and PKCδ did not translocate. Conclusion Brief occlusion of MAO and FAO can protect against myocardial infarction .Their protective mechanism did not pass through the PKC signal passway

which was different from that of myocardiac ischemic preconditioning. The present study may have important clinical implication

because it suggests that ischemia in remote organs can result in cardioprotection when it procedes a coronary thrombotic event.