Objective To investigate the clinicopathologic and differential diagnosis of Bowenoid papulosis. Methods Twelve cases were studied clinicopathologically. The cases were followed -up six months to six years. Results Bowenoid papulosis had a typical morphological characteristic grossly and similar to Bowen’s disease or squamous cell carcinoma histologically

which showed mild to severe hyperplasia of the cells in the spinous layer with easily seen mitoses. Conclusion Bowenoid papulosis is a benign disease .It had mild to severe atypical hyperplasia and similar to Bowen’s disease or squamous cell carcinoma histologically. The disease may be spontaneously regressive and a conservative treatment is advisable.