Objective To investigate the changes of serum precollagen type Ⅲ(PCⅢ)

Iaminin(LN)and hyaluronic acid(HA) in essential hypertensive patients

and influence of benazepril on these parameters. Methods serum PC Ⅲ、LN、HA were measured by radioimmunoassay in 64 essential hypertensive patients before benazepril treatment and after benazepril treatment for four weeks.The correlations between left ventricular mass index (LVM I)and the parameters above mentioned were analyzed. Results Serum PCⅢ

LN and HA were significantly increased in hypertensive patients with LVH as compared with those without LVH and healthy subjects. Serum PC Ⅲ

LN and HA were positively correlated with LVMI in the group of hypertensive patients. Serum PCⅢ、 LN、 HA were significantly decreased in hypertensive patients with or without LVH after benazepril treatment. Conclusion These findings suggest that measurements of PCⅢ

LN and HA may provide indirect diagnostic information on myocardial fibrosis associated with arterial hypertension

and benazepil may prevent hypertensive patients from myocardial fibrosis.