Objective To investigate chemical stability of D-galactosamine hydrochloride solution and give relevant experimental data to making animal model of hepatitis induced by it as well as the preparation and purification of D-GalN HCl. Methods The constant temperature acceleration test was used. The solution concentration was determined on the basis of the determination standard of D-GalN·HCl. The stability of solution was compared with the sample preserved in refrigerator. Results The data of D-GalN·HCl acidic solution (pH=3.0) shows it is stable but its aqueous solution (pH=7.0) unstable. The sample can be stored in refrigerator at 5℃ for 5 days at most

but rapidly decomposed under heating. Conclusion In general

hexosamine aqueous solution is unstable

so the solution in experiments should be pH<7 and can be stored in refrigerator for a short time at pH 7.0.