Objective:To investigate the antibiotic resistance of bacteria clinically isolated from 1994 to 1995 in our hospital. Methods:Bacterial susceptibility to 10 antimicrobial agents was examined with double dilution test. Results:689 clinical bacterial strains isolated in our hospital from 1994 to 1995 were collected in the study

which included 252 Gram positive and 437 Gram negative strains. Results:showed that bacterial resistance to fluoroqinolones increased obviously. The resistant rate of Escherichia coli was >40%. Cefotaxime and cefoperazone still kept potent antibacterial activity

but resistant rate of Psuedomonas aeroginosa to cefoperazone increased to 34%. Amikacin remained a powerful agent against enterobacteriaceae

resistant rate to gentamycin was higher. Most strains were resistant to ampicillin with an increased resistant rate of over 70%. Shigella spp and Samonella typhi were still susceptible to each antibiotics

and the resistant rates were lower than 16%. Conclusion:Bacterial resistance to fluoroquinolones increased obviously

while the third generation cephalosporins and amikacin keep higher antibacterial activity.