自发性高血压大鼠心肌间质重构的实验研究

周建中; 雷寒; 李法琦; 陈运贞

doi:10.13406/j.cnki.cyxb.2000.02.008

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自发性高血压大鼠心肌间质重构的实验研究

更新时间：2024-01-17

- 自发性高血压大鼠心肌间质重构的实验研究
- The study of remodeling of myocardium mesenchyme in spontaneous hypertensive rats
- 重庆医科大学学报 2000年第2期页码：131-133
- 作者机构：
  
  重庆医科大学临床学院心血管内科,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.02.008
  中图分类号： R544.1
- 纸质出版日期：2000，
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[1]周建中,雷寒,李法琦,陈运贞.自发性高血压大鼠心肌间质重构的实验研究[J].重庆医科大学学报,2000(02):131-133.

The study of remodeling of myocardium mesenchyme in spontaneous hypertensive rats[J]. Journal of Chongqing Medical University, 2000,(2):131-133.
[1]周建中,雷寒,李法琦,陈运贞.自发性高血压大鼠心肌间质重构的实验研究[J].重庆医科大学学报,2000(02):131-133. DOI： 10.13406/j.cnki.cyxb.2000.02.008.

The study of remodeling of myocardium mesenchyme in spontaneous hypertensive rats[J]. Journal of Chongqing Medical University, 2000,(2):131-133. DOI： 10.13406/j.cnki.cyxb.2000.02.008.

摘要

目的 :观察高血压心肌间质重构。方法 :采用不同月龄自发性高血压大鼠（SHR）为实验动物模型

从胶原定性和定量指标观察心肌间质重构。结果 :SHR10 与WKY10 比较

胶原面积（CA）及胶原容积分数（CVF）增高 1.4倍 ;SHR18-2 2 最高

与SHR10 比较CA、CVF增高 2 .4倍（P <0 .0 1）。CVF比左室重量指数（LVW/BW ）增加更明显

结论 :SHR心肌间质、冠脉血管均发生了重构

SHR18-2 2 心肌间质重构程度明显加重

其程度加重可能是导致心力衰竭的重要原因之一。

Abstract

Objective:To observe the remodeling of myocardium mesenchyme in hypertention. Methods:Using spontaneous hypertensive rats (SHR) of different age in months as experiment models to observe the remodeling of myocardium mesenchyme by collagen in quality and quantity. Results:The collagen areas (CA) or collagen volume fraction (CVF) were the highest in SHR 18-22 . CA or CVF of SHR 10 increased 1.4 times compared with WKY 10 and CA or CVF of SHR18-22 increased 2.4 times compared with SHR10 (P<0.01). It was found that CVF was increased prominently than left ventricular weight index (LVW/BW). Conclusion: Myocardium mesenchyme or vessels in SHR appeared remodeled and the remodeling was distinctly aggravating in SHR18-22. The aggravation of remodeling might be one of the important reasons resulting in CHF.

关键词

自发性高血压大鼠心肌间质重构胶原

Keywords

Spontaneous hypertensive ratMyocardium mesenchyme remodelingCollagen

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