A study on the relationship between the infection of human cytomegalovirus(HCMV) and the variation of kinetochore[J]. Journal of Chongqing Medical University, 2000,(2):113-114.
A study on the relationship between the infection of human cytomegalovirus(HCMV) and the variation of kinetochore[J]. Journal of Chongqing Medical University, 2000,(2):113-114. DOI: 10.13406/j.cnki.cyxb.2000.02.001.
Objective:We studied the relationship between the infection of HCMV and the variation of kinetochore
researched the mechanism of causing abnormal growth embryo. Methods:Kinetochore (centromeric dots
Cd) of chorionic villus or embryo tissue of 15 HCMV-DNA(PCR) positive and 25 HCMV-DNA(PCR) negative pregnant women were studied by Cd-banding techniques. Results:The frequency of Cd loss and Cd size variation in positive group were significantly higher than those in negative group. Conclusion:The study indicated that Cd variation caused by HCMV infection play an important role in form of birth defect. Cd banding analysis in chorionic villus or embryo tissue of HCMV-DNA(PCR) positive pregnant women could evaluate the risk of abnormal growth embryo.