以HPV基因通用引物行PCR检测阴茎肿瘤组织中HPV.DNA

王德林; 何士元; 乔天愚

doi:10.13406/j.cnki.cyxb.2000.01.011

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以HPV基因通用引物行PCR检测阴茎肿瘤组织中HPV.DNA

更新时间：2024-01-17

- 以HPV基因通用引物行PCR检测阴茎肿瘤组织中HPV.DNA
- Detection of human papillomavirus (HPV) DNA in penile neoplasm by general primer mediated polymerase chain reaction
- 重庆医科大学学报 2000年第1期页码：33-34
- 作者机构：
  
  1. 重庆医科大学临床学院泌尿科,400016
  2. 重庆医科大学第二临床学院泌尿科,400010
  3. 重庆医科大学临床学院泌尿科!400016重庆医科大学第二临床学院泌尿科,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.01.011
  中图分类号： R730.4
- 纸质出版日期：2000，
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[1]王德林,何士元,乔天愚.以HPV基因通用引物行PCR检测阴茎肿瘤组织中HPV.DNA[J].重庆医科大学学报,2000(01):33-34+32.

WANG De-lin, et al. Detection of human papillomavirus (HPV) DNA in penile neoplasm by general primer mediated polymerase chain reaction[J]. Journal of Chongqing Medical University, 2000,(1):33-34.
[1]王德林,何士元,乔天愚.以HPV基因通用引物行PCR检测阴茎肿瘤组织中HPV.DNA[J].重庆医科大学学报,2000(01):33-34+32. DOI： 10.13406/j.cnki.cyxb.2000.01.011.

WANG De-lin, et al. Detection of human papillomavirus (HPV) DNA in penile neoplasm by general primer mediated polymerase chain reaction[J]. Journal of Chongqing Medical University, 2000,(1):33-34. DOI： 10.13406/j.cnki.cyxb.2000.01.011.

摘要

为了探讨人乳头瘤病毒感染与阴茎肿瘤的关系。用人乳头瘤病毒基因通用引物行聚合酶链反应，检测５２例阴茎鳞癌。ＨＰＶ阳性率为６７％，３１例为ＨＰＶ－１６，３例为ＨＰＶ１６／１８，１例为ＨＰＶ１１／１８。４例阴茎癌淋巴结转移灶标本，３例检出与原发癌一致的ＨＰＶ．ＤＮＡ。６例阴茎乳头状瘤标本，４例检出ＨＰＶ－６或１１。２０例正常阴茎包皮均阴性。提示ＨＰＶ在阴茎肿瘤的发生发展中有一定的作用，但与肿瘤的病理分级无关。

Abstract

The Purpose of this study was to investigate the relationship bewteen HPV infection and penile neoplasm. Using general primer mediated polymerase chain reaction(PCR) assay

The HPV. DNA was detected in 52 penile squamous cell carcinomas. The HPV.DNA positive rate was 67%.HPV-16 was identified in 31 cases

HPV16/18 in 3 and HPV11/18 in 1. HPV.DNA was also detected in 3 of 4 cases of lymph node metastasis of penile carcionoma

and they beloned to the same type of HPV as the primary carcinoma. HPV-6 or 11 was found in 4 of 6 penile papillomas. As controls

HPV had not been detected in any of 20 nonneoplastic foreskins. These data indicate that HPV is strongly associated with penile neoplasm and may play an etiologic role in the development of these neoplasms.

关键词

聚合酶链反应人乳头瘤病毒阴茎肿瘤

Keywords

Polymerase chain reationhuman papillomaviruspenile neoplasms.

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