WANG Zhong-Feng, et al. Effects of tetrandrine on calcium channels in rat cortical neurons[J]. Journal of Chongqing Medical University, 2000,(1):18-19.
WANG Zhong-Feng, et al. Effects of tetrandrine on calcium channels in rat cortical neurons[J]. Journal of Chongqing Medical University, 2000,(1):18-19. DOI: 10.13406/j.cnki.cyxb.2000.01.006.
The effects of tetrandrine (Tet ) on calcium channels in acutely isolated rat conical neurons were studied using the patch clamp single channel recording technique. The results indicated that Tet (7.5μ moll
15 μ moll and 30 μ mol/L ) inhibited the L- and N- type calcium channels in a concentration-dependent manner. The open times of L- and N- type calcium channels decreased
the closed times increased
and open-state probability decreased. The effects of Tet on L-type calcium charmel were consistent with verapamil
a typical calcium channel antagonist
but were weaker than those of verapamil. On the other hands
the N-type calcium channel blocking effects of Tet were much stronger than those of verapamil. The multifunctions of Tet might be related to its antagonist effect on the calcium charmels.