Yang Shuqun, et al. Distribution and pharmacokinetics after intravenous injection of ciprofloxacin in the rabbit eye[J]. Journal of Chongqing Medical University, 1999,(4):376-380.
Yang Shuqun, et al. Distribution and pharmacokinetics after intravenous injection of ciprofloxacin in the rabbit eye[J]. Journal of Chongqing Medical University, 1999,(4):376-380. DOI: 10.13406/j.cnki.cyxb.1999.04.014.
The intraocular concentration of ciprofloxacin was measured by high performance liquid chromatographyafter single intravenous injection ciprofloxacin in the rabbit eye. The peak concentrations (Cmax) ofciprofloxacin in lachrymal fluid
cornea
aqueous humour
iris - ciliary body
lens
vitreous body were 8.92±2.88
142.84±32.02
11.06±2.80
99.32±10.60
30.28±1.91 and 8.10±1.71ug/g. ml
respectively. The half - life(t1/2 ) ofvarious concentrations in lachrymal fluid
cornea
aqueous humour
iris-ciliary body
lens and vitreous bodywas 1.49± 0.97
1.66±10.13
2.09±0.51
2.01±0.44
1.52±0.92 and 1.21±0.66h
respectively. The results indicate thatciprofloxacin can penetrate intraocular various tissure.