EFFECT OF NIFEDIPINE ON PHARMACOKINETICS OF PRAZIQUANTEL IN RATS[J]. Journal of Chongqing Medical University, 1993,(4):251-254. DOI: 10.13406/j.cnki.cyxb.1993.04.001.
A previous study in our laboratory had shown that n ifedipine(NF) as acalci-um antagonist
competitively inhibited the metabolism of praziquantel (PQT) enantiomers in human and rat liver microsomes in vitro. In this paper
we studied the effect of NF on the plasma concentration of PQT in rats. After Ig injections of PQT 100 mg/kg to male Wistar rats
the plasma levels of PQT were determined by reverse HPLC. The results shown by
(that)tho pharmacokinetic parameters (AUC
MRT
CL
Tmax and Cmax) of PQT in NF (a single ip injection of 40 mg/kg) -pretreated rats were not significantly differ3nt as compared with that of control rats. The data from our investigation demonstrated that NF had no effects on the pharmacokinetics of PQT in rats in vivo