In this present study the dynamic changes ot the level of malondialdehyde (MDA)

the activity of superoxide dismutase (SOD) in liver and kidney and the value of SGPT in plasma of the experimental Fulminant Hepatic Failure-(FHF) rats

as well as the effects and influences of SOD and CAT given parente rally in FHF model rats were observed. Our results revealed that after the formation of FHF the level of MDA in liver and the value of SGPT in plasma were markedly elevated

the activities of SOD in liver was decreased graduaally but the change of the values determined in the kidney was not so notable as compared with those in the liver. According to our data the FHF rats revealed no-positive response to the administration of SOD and CAT.It is suspected that the action of Hpid peroxidation mediated by free radicals might take part in the formation of FHF and probably develop a distant effect of the injury on the kidney