糖尿病红细胞膜Na<sup>+</sup>—K<sup>+</sup>—ATP酶活性的改变及其影响因素

邓华聪; 邱鸿鑫; 汪恕萍; 罗荣; 沈萍菇; 粟绍初

doi:10.13406/j.cnki.cyxb.1992.03.008

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糖尿病红细胞膜Na⁺—K⁺—ATP酶活性的改变及其影响因素

更新时间：2024-01-17

- 糖尿病红细胞膜Na⁺—K⁺—ATP酶活性的改变及其影响因素
- THE CHANGE OF NA⁺-K⁺-ATPase ACTIVITY IN ERYTHROCYTES FROM NIDDM PATIENTS
- 重庆医科大学学报 1992年第3期页码：193-197
- 作者机构：
  
  重庆医科大学第一医院内科内分泌组
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1992.03.008
  中图分类号：
- 纸质出版日期：1992，
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[1]邓华聪,邱鸿鑫,汪恕萍,罗荣,沈萍菇,粟绍初.糖尿病红细胞膜Na~+—K~+—ATP酶活性的改变及其影响因素[J].重庆医科大学学报,1992(03):193-197+178.

THE CHANGE OF NA⁺-K⁺-ATPase ACTIVITY IN ERYTHROCYTES FROM NIDDM PATIENTS[J]. Journal of Chongqing Medical University, 1992,(3):193-197.
[1]邓华聪,邱鸿鑫,汪恕萍,罗荣,沈萍菇,粟绍初.糖尿病红细胞膜Na~+—K~+—ATP酶活性的改变及其影响因素[J].重庆医科大学学报,1992(03):193-197+178. DOI： 10.13406/j.cnki.cyxb.1992.03.008.

THE CHANGE OF NA⁺-K⁺-ATPase ACTIVITY IN ERYTHROCYTES FROM NIDDM PATIENTS[J]. Journal of Chongqing Medical University, 1992,(3):193-197. DOI： 10.13406/j.cnki.cyxb.1992.03.008.

摘要

本文探讨了50例Ⅱ型糖尿病（NIDDM）患者Na

-K

-ATP酶活性的改变与红细胞变形能力（RCD）的关系以及与其活性有关的其它因素.结果表明

与正常对照组比较

NIDDM患者红细胞膜Na

-K

-ATP酶活性与Mg

-ATP酶活性明显降低;而红细胞滤过指数（IF）、红细胞膜胆固醇（Ch）、膜脂质过氧化物（Lpo）、空腹血糖（FBG）、糖化血红蛋白（HbA

C）则明显升高

上述改变在NIDDM伴有视网膜病变者中更为明显.直线相关分析表明

NIDDM患者红细胞膜Na

-K

-ATP酶活性与Mg

-ATP酶活性呈正相关;与红细胞IF、膜Ch、膜Lpo、FBG、HbA

C呈负相关.提示NIDDM患者红细胞膜Na

-K

-ATP酶活性的改变可能是导致RCD降低的重要因素之一

Abstract

Na+-K+-ATPase activity of the erythrocyte plasma membrane in noninsulin-de- pendent diabetes mellitus (NIDDM) was studied together with the red cell deform-ability (RCD) and other influencing factors. Comparing with the normal controls

Na+-K+-ATPase activity

Mg++-ATPase activity

and RCD in diabetics were significantly decreased

and the erythrocyte membrane cholesterol and lipid peroxide

fasting blood glucose

and glycosylated hemoglobin were significantly increased. The change of Na+-K+-ATPase activity was positively correlated with RCD

and inversely correlated with fasting blood glucose

erythrocyte membrane cholesterol

and lipid peroxide. The results suggested that the change of Na+-K+-ATPase activity in erythrocyte may contribute to the alterations of RCD in diabetics

关键词

Ⅱ型糖尿病红细胞膜Na+-K+-ATP酶红细胞变形能力

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糖尿病红细胞膜Na+—K+—ATP酶活性的改变及其影响因素

THE CHANGE OF NA+-K+-ATPase ACTIVITY IN ERYTHROCYTES FROM NIDDM PATIENTS

DOI：10.13406/j.cnki.cyxb.1992.03.008

摘要

Abstract

关键词

Keywords

references

糖尿病红细胞膜Na⁺—K⁺—ATP酶活性的改变及其影响因素

THE CHANGE OF NA⁺-K⁺-ATPase ACTIVITY IN ERYTHROCYTES FROM NIDDM PATIENTS