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重庆医科大学检验系
纸质出版日期:1992,
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[1]王荣光,王霞文.五项衰老生化指标的探讨[J].重庆医科大学学报,1992(01):31-34.
EVALUATION FOR FIVE INDICATORS FOR AGING[J]. Journal of Chongqing Medical University, 1992,(1):31-34.
[1]王荣光,王霞文.五项衰老生化指标的探讨[J].重庆医科大学学报,1992(01):31-34. DOI: 10.13406/j.cnki.cyxb.1992.01.007.
EVALUATION FOR FIVE INDICATORS FOR AGING[J]. Journal of Chongqing Medical University, 1992,(1):31-34. DOI: 10.13406/j.cnki.cyxb.1992.01.007.
本文观察了2月、10月和24月龄大鼠红细胞膜Na
+
-K
-ATP酶、全血谷胱甘肽过氧化物酶(GSH-PX)
红细胞超氧化物歧化酶(SOD)活性及红细胞膜和血浆脂质过氧化物(LP0)水平
结果显示10月龄与2月龄组相比
Na
-ATP酶活性增高24.16%.GSH-PX活性增高4o.07%.红细胞膜LPO增高44.44%
血浆LPO增高了102.72%;24月龄与10月龄组相比
-ATP酶活性下降45.16%
GSH-PX活性下降了22.3%
SOD活性下降12.32%
而红细胞膜LPO升高30.0%.由此认为上述5项指标可用于评估机体衰老情况
The following indexes of 2
10 and 24 months old wistar rats were measured. the activities of RBC membrane Na+-K+-ATPase
RBC superoxide dismutasc (SOD)
blood glutathione. peroxidase (GSH-Px)
and the levels of lipid peroxides (EPO) in plasma and RBC membrane From 2 to 10 month-old animals
increases of 24.16%
40.07%
102.7% and 44.44%in Na-K-ATPase activity
GSH-Px activity
plasma LPO and RBC membra no LPO levels
respectively
were found (P<0.01). In 24 month-old rats
the activity of Na+-K+-ATPase
SOD and GSH-Px delined by 45.17%
12.32% and 22.39%
while the LPO level in RBC membrane rose by 30% (P<0.01). These results show that the 5 parameters change with aging
and can serve as biochemical indicators for aging
大鼠衰老超氧化物歧化酶谷胱甘肽过氧化物酶脂质过氧化物Na+-K+-ATP酶
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