脑脊液髓鞘碱性蛋白片段的酶联免疫测定及其临床意义

向敬; 董为伟; 吴渝宪

doi:10.13406/j.cnki.cyxb.1991.04.012

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脑脊液髓鞘碱性蛋白片段的酶联免疫测定及其临床意义

更新时间：2024-01-17

- 脑脊液髓鞘碱性蛋白片段的酶联免疫测定及其临床意义
- CLINICAL SIGNIFICANCE OF ENZYME-LINKED IMMUNOSORBENT ASSAYS FOR MYEL1N BASIC PROTEIN FRAGMENTT IN CEREBROSP1NAL FLUID
- 重庆医科大学学报 1991年第4期页码：311-314
- 作者机构：
  
  重庆医科大学神经病学研究所
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1991.04.012
  中图分类号：
- 纸质出版日期：1991，
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[1]向敬,董为伟,吴渝宪.脑脊液髓鞘碱性蛋白片段的酶联免疫测定及其临床意义[J].重庆医科大学学报,1991(04):311-314+351.

CLINICAL SIGNIFICANCE OF ENZYME-LINKED IMMUNOSORBENT ASSAYS FOR MYEL1N BASIC PROTEIN FRAGMENTT IN CEREBROSP1NAL FLUID[J]. Journal of Chongqing Medical University, 1991,(4):311-314.
[1]向敬,董为伟,吴渝宪.脑脊液髓鞘碱性蛋白片段的酶联免疫测定及其临床意义[J].重庆医科大学学报,1991(04):311-314+351. DOI： 10.13406/j.cnki.cyxb.1991.04.012.

CLINICAL SIGNIFICANCE OF ENZYME-LINKED IMMUNOSORBENT ASSAYS FOR MYEL1N BASIC PROTEIN FRAGMENTT IN CEREBROSP1NAL FLUID[J]. Journal of Chongqing Medical University, 1991,(4):311-314. DOI： 10.13406/j.cnki.cyxb.1991.04.012.

摘要

从牛脊髓髓鞘碱性蛋白（MBP）分离出三种MBP片段;建立了脑脊液MBP片段的酶联免疫检测法.初步临床研究表明

脑脊液MBP片段P1有重要的临床意义

与完整MBP相比

其诊断灵敏度明显提高

更能反映多发性硬化的脱髓鞘活动及临床病情

Abstract

The Enzyme-Linked Immunosorbent Assay (ELISA) for Myelin Basic Protein (MBP) fragments (termed as MBP-P1

MBP-P2 and MBP-P3) were developed in present study. The intact MBP and MBP fragments in cerebrospinal fluid were detected in 34 patients-with Multiple Sclerosis(MS)and 30 patients with other neurological disorders ( OND). The results demonstrated that

only MBP-Pl and intact MBP were there being a significant difference between patients with MS and control subjects (p<0.01). The diagnostic sensitivity of MBP-Pl (76%)was higher than that of MBP (62%)

the levels of MBP-Pl was the highest in MS group

and there was close correlation between levels of MBP-P1 and Millar’s score (r = 0.730

p< 0.05). We consider that the MBP-P1 in cerebrospinal fluid is a useful laboratory index of demyelination in MS

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髓鞘碱性蛋白髓鞘碱性蛋白片段脑脊液酶联免疫测定法

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