A follow-up observation of 222 HBsAg carriers was carried out over four years. The serological results showed that 46 out of 222 HBsAg carriers were negative converted (20.7%)

25 out of 72 HBeAg positive carriers were negative converted (34.72%). The clinical results showed that 12 suffered from acute hepatitis

10 from chronic persistent hepatitis (CPH)

8 chronic active hepatitis(CAH)

3 hepa-tocirrhosis

1 primary hepatic carcinoma (PHC)

25 with slight liver function damage

117 were asymptomatic carriers

and 46 persons recovered.This follow-up study indicated that the negative-conversion rate of HBsAg carriers with high titer or HBeAg positive was significantly lower than those with low titer or HBeAg negative and that the negative-conversion rate of HBsAg carriers or HBeAg positive increased with age