A follow-up study of the dynamic changes with multiple parameters of blood coagulation and plasma limulus assay was carried out in 20 patients with decompen-sated hepatic cirrhosis.It was found that the levels of endotoxin in peripheral blood and factor VIII-related antigen increased significantly

prothrombin time and kaolin partial thromboplastin time prolonged

whereas fibrinogen

factor II

hepaplastin test

antithrombin-III and fibronectin decreased.Our data suggested that( 1 )both the coagulation abnormalities and endotoxemia were coexisted and correlated progressively with the disease process. ( 2 )the incidence and severity of endotoxemia were closely correlated with the degree and severity of hepatic decompensation; ( 3 )dynamic charges of endotoxemia and coagulation abnormalities were of some prognostic significance in decompensated hepatic cirrhosis