肝脏疾病疑血功能障碍与内毒素血症

戴立里; 徐葆元

doi:10.13406/j.cnki.cyxb.1989.03.010

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肝脏疾病疑血功能障碍与内毒素血症

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- 肝脏疾病疑血功能障碍与内毒素血症
- HEMOSTATIC PROBLEMS AND ENDOTOXEMIA IN LIVER DISEASE
- 重庆医科大学学报 1989年第3期页码：205-209
- 作者机构：
  
  1. 重庆医科大学第二医院
  2. 重庆医科大学第二医院研究生
  3. 重庆医科大学第二医院重庆医科大学第二医院研究生
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1989.03.010
  中图分类号：
- 纸质出版日期：1989，
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[1]戴立里,徐葆元.肝脏疾病疑血功能障碍与内毒素血症[J].重庆医科大学学报,1989(03):205-209.

Dai Lelee & Xu Baoyuan. HEMOSTATIC PROBLEMS AND ENDOTOXEMIA IN LIVER DISEASE[J]. Journal of Chongqing Medical University, 1989,(3):205-209.
[1]戴立里,徐葆元.肝脏疾病疑血功能障碍与内毒素血症[J].重庆医科大学学报,1989(03):205-209. DOI： 10.13406/j.cnki.cyxb.1989.03.010.

Dai Lelee & Xu Baoyuan. HEMOSTATIC PROBLEMS AND ENDOTOXEMIA IN LIVER DISEASE[J]. Journal of Chongqing Medical University, 1989,(3):205-209. DOI： 10.13406/j.cnki.cyxb.1989.03.010.

摘要

本研究发现肝病患者常发生内毒素血症

其发生率的高低与肝脏病变的损伤程度和范围相平行

与枯否细胞吞噬功能有关。肝病的凝血障碍属多因子性

不仅有凝血因子的改变

也有抗凝血酶Ⅲ的降低。多元线性相关分析揭示:内毒素血症发生率与Fn

凝血因子异常和AT-Ⅲ的变化显著相关（P<0.001）

其中以HPT、FⅡ、AT-Ⅲ、Fn、ⅧR:Ag与内毒素血症的相关性更为密切

提示在引起肝脏疾病凝血功能障碍的诸因素中

不可忽视内毒素血症的存在

Abstract

Plasma Limulus Lysate assay

fibronectin

blood coagulation picture (Fbg

FⅡ

HPT

ⅧR:Ag) and antithrombin-Ⅲ were determined in G1 patients with liver disease. The frequency of endotoxemia depended upon the degree and extent of hepatic injury and the phagocytic activity of the Kupffer cells. The coagulation abnormalities were multifactorial

there were not only the changes of clotting proteins

but also the diminution of antithrombin-Ⅲ. Multivariate analysis showed that the frequency of endotoxemia was closely correlated with the changes of fibronectin

clotting proteins and antithrombin-III (P<0.001)

among which the changes of HPT

FⅡ

AT-Ⅲ

VIIIR:Ag were statistically significant. Our data suggested that among these factors

which cause clotting abnormalities in liver disease

the endotoxemia should not be ignored

关键词

内毒素血症鲎试验凝血异常纤维蛋白连接素

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