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1. 重庆医科大学血吸虫病研究室
2. 重庆医科大学儿科医院儿童保健教研室
3. 日本东京慈惠会医科大学寄生虫学教研室
纸质出版日期:1989,
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[1]陈雅棠,刘约翰,郑惠莲,梅其霞,陈永芬,小林昭夫.弓形体感染与儿童智力发育障碍的初步研究[J].重庆医科大学学报,1989(02):91-94.
Chen Yatang, et al. A PRELIMINARY STUDY ON RELATIONSHIP BETWEEN TOXOPLASMA INFECTION AND INTELLIGENCE DEFICIENCY IN CHILDEN[J]. Journal of Chongqing Medical University, 1989,(2):91-94.
[1]陈雅棠,刘约翰,郑惠莲,梅其霞,陈永芬,小林昭夫.弓形体感染与儿童智力发育障碍的初步研究[J].重庆医科大学学报,1989(02):91-94. DOI: 10.13406/j.cnki.cyxb.1989.02.003.
Chen Yatang, et al. A PRELIMINARY STUDY ON RELATIONSHIP BETWEEN TOXOPLASMA INFECTION AND INTELLIGENCE DEFICIENCY IN CHILDEN[J]. Journal of Chongqing Medical University, 1989,(2):91-94. DOI: 10.13406/j.cnki.cyxb.1989.02.003.
用乳胶凝集试验(Latex agglutination)和酶联免疫吸附试验(Enzyme-Iinked immunosorbent assay)检测79对弱智儿童及母亲、107对智力正常儿童及母亲血清弓形体抗体。结果表明:两法有良好一致性。两项试验双阳性率依次为6.33
8.86、0和0.93%。弱智组双阳性率显著为高(P<0.05)。19例合并先天性畸形的弱智儿童双阳性率为15.7%
显著高于智力正常儿童或无先天性畸形的弱智儿童(0%
3.33%
P<0.01)。因此
弓形体感染可能是造成儿童智力发育障碍的病因之一
并与儿童先天性畸形有一定关系。建议国内对孕妇常规进行血清弓形体抗体检查。
This paper reports the results of latex agglutination (LA) and enzyme-linked immunoso-rbent assay (ELISA) for detecting the specifie anti-Toxoplasma antibody positive rates among 79 cases of intelligence deficiency children and their mothers
and 107 cases of intelligence-normal children and their mothers. The results indicated that between the results of LA and ELISA a good coincidence was presented.The anti-Toxoplasma antibody both positive rates of LA and ELISA wen: 6.38
8.36
O and 0.93% respectively. The both positive raves of intelligence deficiency children and mothers group were signifiantly higher than that of intelligence-normal children and mothers group. In 19 intelligence deficiency children with congenital malformation
the both positive rate was 15.79%
and was significantly higher than that of 107 intelligence-normal children (0%)
and 60 intelligence deficiency without congenital malformation children (3.33%) respectively. Therefore
Toxoplasma infection may be one of the potential pathogenic causes of intelligence deficiency and congenital malformation in children. We suggest that routine examinations for anti-Toxoplasma antibody in pregnant women be carried out
弓形体智力障碍乳胶凝集试验酶联免疫吸附试验
T6xoplasmaIntelligerce deficiencyLatex agglutination (LA)Enzyme- linked immunosorbent assay (ELISA)
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