硒与肿瘤 Ⅲ、植瘤小鼠给抑瘤剂量硒后胞浆中<sup>75</sup>Se的分布与含硒蛋白变化

颜学先; 王鼎年

doi:10.13406/j.cnki.cyxb.1989.02.001

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硒与肿瘤 Ⅲ、植瘤小鼠给抑瘤剂量硒后胞浆中⁷⁵Se的分布与含硒蛋白变化

更新时间：2024-01-17

- 硒与肿瘤 Ⅲ、植瘤小鼠给抑瘤剂量硒后胞浆中⁷⁵Se的分布与含硒蛋白变化
- SELENIUM AND CANCER Ⅲ. THE DISTRIBUTION OF 75-SE, GPX AND SELENOPROTEINS IN THE CYTOSQLS OF TUMOR BEARING NICE TREATED WITH ANTICARCINOGENIC SELENIUM
- 重庆医科大学学报 1989年第2期页码：85-90
- 作者机构：
  
  重庆医科大学基础核医学教研室
- 作者简介：
- 基金信息：
  
  四川省卫生厅科研课题
- DOI：10.13406/j.cnki.cyxb.1989.02.001
  中图分类号：
- 纸质出版日期：1989，
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[1]颜学先,王鼎年.硒与肿瘤 Ⅲ、植瘤小鼠给抑瘤剂量硒后胞浆中~(75)Se的分布与含硒蛋白变化[J].重庆医科大学学报,1989(02):85-90.

Yan Xuexian Wang Dingnian. SELENIUM AND CANCER Ⅲ. THE DISTRIBUTION OF 75-SE, GPX AND SELENOPROTEINS IN THE CYTOSQLS OF TUMOR BEARING NICE TREATED WITH ANTICARCINOGENIC SELENIUM[J]. Journal of Chongqing Medical University, 1989,(2):85-90.
[1]颜学先,王鼎年.硒与肿瘤 Ⅲ、植瘤小鼠给抑瘤剂量硒后胞浆中~(75)Se的分布与含硒蛋白变化[J].重庆医科大学学报,1989(02):85-90. DOI： 10.13406/j.cnki.cyxb.1989.02.001.

Yan Xuexian Wang Dingnian. SELENIUM AND CANCER Ⅲ. THE DISTRIBUTION OF 75-SE, GPX AND SELENOPROTEINS IN THE CYTOSQLS OF TUMOR BEARING NICE TREATED WITH ANTICARCINOGENIC SELENIUM[J]. Journal of Chongqing Medical University, 1989,(2):85-90. DOI： 10.13406/j.cnki.cyxb.1989.02.001.

摘要

植H615肝癌实体瘤的615纯种小鼠

于植瘤后第15天开始每隔5天腹腔注射2ugSe/g体重的亚硒酸钠及示踪剂量

给硒6次后处死

通过葡聚糖凝胶层析观察

Se在红细胞、肝及瘤细胞胞浆中的分布。结果发现:胞浆中不仅GPX上结合有硒

也存在着其它的含硒蛋白质;营养水平的硒和抑瘤水平的硒在红细胞、肝及瘤胞浆中的分布情况不同;同一水平的硒在植瘤和未植瘤鼠上述胞浆内的分布也不同。并伴有GPX和其它含硒蛋白质改变。这些现象可能与硒的抑瘤作用有联系

Abstract

2 ppm selenium as Na2SeO3 and tracer 75-Se-selenite was administered to 615 mire inoculated with liver solid tumor six times over a 40-day period by ip. iniection. All mice were killed on the 45th day following tumor cell inoculation. The cytosols of RBC

liver and tumor cell were chromatographed on a Sephadex G-150 column separately. The 75-Se cpm

GPX activity and absorbance at 280 (or 540) nm of each collection were determined. The results showed that several Se-containing proteins except GPX exist in the cytosols; There are some differences about distribution of 75-Se in all of the three oytosols between the mice given nutritional or aaticarcinogenic selenium and with or without bearing tumor; The GPX and selenoproteins have also some; significant chauges. It is suggested chat these beh a-viors are probably responsible for this trace element’s anticarcinogenic properties

关键词

75Se—Na2SeO3谷胱甘肽过氧化物酶含硒蛋白质硒的抑瘤特性

Keywords

7ō-Se-seleniceGlutathioae peroxidaseSeleaoproteinsAaticaccinogenie property of selenium

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硒与肿瘤 Ⅲ、植瘤小鼠给抑瘤剂量硒后胞浆中75Se的分布与含硒蛋白变化

SELENIUM AND CANCER Ⅲ. THE DISTRIBUTION OF 75-SE, GPX AND SELENOPROTEINS IN THE CYTOSQLS OF TUMOR BEARING NICE TREATED WITH ANTICARCINOGENIC SELENIUM

DOI：10.13406/j.cnki.cyxb.1989.02.001

摘要

Abstract

关键词

Keywords

references

硒与肿瘤 Ⅲ、植瘤小鼠给抑瘤剂量硒后胞浆中⁷⁵Se的分布与含硒蛋白变化