急性心力衰竭大鼠心房肌提取物的生理活性

杜晓军

doi:10.13406/j.cnki.cyxb.1988.03.004

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急性心力衰竭大鼠心房肌提取物的生理活性

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- 急性心力衰竭大鼠心房肌提取物的生理活性
- THE ALTERATIONS OF RENAL AND HEMODYNAMIC EFFECTS OF NATRIURETIC FACTOR IN ATRIA OF THE RATS WITH ACUTE HEART FAILURE
- 重庆医科大学学报 1988年第3期页码：179-185
- 作者机构：
  
  重庆医科大学病理生理学教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1988.03.004
  中图分类号：
- 纸质出版日期：1988，
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[1]杜晓军.急性心力衰竭大鼠心房肌提取物的生理活性[J].重庆医科大学学报,1988(03):179-185.

Department of Pathophysiology Du Xiaojun. THE ALTERATIONS OF RENAL AND HEMODYNAMIC EFFECTS OF NATRIURETIC FACTOR IN ATRIA OF THE RATS WITH ACUTE HEART FAILURE[J]. Journal of Chongqing Medical University, 1988,(3):179-185.
[1]杜晓军.急性心力衰竭大鼠心房肌提取物的生理活性[J].重庆医科大学学报,1988(03):179-185. DOI： 10.13406/j.cnki.cyxb.1988.03.004.

Department of Pathophysiology Du Xiaojun. THE ALTERATIONS OF RENAL AND HEMODYNAMIC EFFECTS OF NATRIURETIC FACTOR IN ATRIA OF THE RATS WITH ACUTE HEART FAILURE[J]. Journal of Chongqing Medical University, 1988,(3):179-185. DOI： 10.13406/j.cnki.cyxb.1988.03.004.

摘要

应用冠脉结扎技术和生物测定法

观察急性心力衰竭（HF）大鼠心房肌提取物（AE）中心房钠尿因子（ANF）活性的改变.结果提示

急性HF时心房ANF含量和（或）活性的改变与慢性HF时有差别

心房肌肥大可能通过增加ANF的合成、贮存和释放过程而起到重要的代偿作用

Abstract

The renal and hemodynamin responses of normal assay rats to atrial extracts (AE) of the rats with acute heart failure (HF) induced by coronary ligation and of the sham-operated control rats were assessed four days after the operation. The hypotensive action was similar in the two groups of AE

but the AE of HF rats showed stronger diuretic (1077±136 vs 818±116μ1/10 min

P=0.05) and natriuretic effects (161±25vs 120±17μmol/10 min

P< 0.025) than control AE. Inversely

the negatively chronotropic effect of AE from HF rats was weaker compaired with that of control AE (P<0.05). A significant increase of atrial weight in HF rats was observed (146±11vs 93±5mg

P<0.001). These results suggest 1) in the acute phase of HF

changes of the total content and/or bioactivity of atrial natriuretic factor (ANF) in atria is different from that observed ia chronic HF

and 2) hypertrophy of atrial myocyte may play an important compensatory role in the early phase of HF through the enhancement of synthesis

storage

and release of ANF

关键词

心房钠尿因子心力衰竭心肌梗死心房大鼠生物测定法心肌肥大

Keywords

Atriai Natriuretic Factorheart failuremyocardial infarctionAtriumratMyocardial HypertrophyBioassay

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