T细胞及IL-2对乙肝患者B细胞体外产生抗HBS的免疫调控作用

刘邦媛; 张定凤; 陈学华

doi:10.13406/j.cnki.cyxb.1988.03.002

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T细胞及IL-2对乙肝患者B细胞体外产生抗HBS的免疫调控作用

更新时间：2024-01-17

- T细胞及IL-2对乙肝患者B细胞体外产生抗HBS的免疫调控作用
- THE IMMUNOREGULATORY EFFECTS OF IL-2 AND T CELL ON ANTI-HBs SYNTHESIS IN VITRO BY B CELLS FROM HBV INFECTIONS
- 重庆医科大学学报 1988年第3期页码：169-172
- 作者机构：
  
  重庆医科大学第二医院肝炎研究所
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1988.03.002
  中图分类号：
- 纸质出版日期：1988，
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[1]刘邦媛,张定凤,陈学华.T细胞及IL-2对乙肝患者B细胞体外产生抗HBS的免疫调控作用[J].重庆医科大学学报,1988(03):169-172.

THE IMMUNOREGULATORY EFFECTS OF IL-2 AND T CELL ON ANTI-HBs SYNTHESIS IN VITRO BY B CELLS FROM HBV INFECTIONS[J]. Journal of Chongqing Medical University, 1988,(3):169-172.
[1]刘邦媛,张定凤,陈学华.T细胞及IL-2对乙肝患者B细胞体外产生抗HBS的免疫调控作用[J].重庆医科大学学报,1988(03):169-172. DOI： 10.13406/j.cnki.cyxb.1988.03.002.

THE IMMUNOREGULATORY EFFECTS OF IL-2 AND T CELL ON ANTI-HBs SYNTHESIS IN VITRO BY B CELLS FROM HBV INFECTIONS[J]. Journal of Chongqing Medical University, 1988,(3):169-172. DOI： 10.13406/j.cnki.cyxb.1988.03.002.

摘要

本文采用抗HBS间接空斑法

测定了临床各型乙肝43例及疫苗接受者20例的B细胞产生抗HBS的能力

发现各型乙肝病人产生抗HBS的能力

与疫苗接受者比较有明显降低

而重症肝炎则稍高.各型乙肝病人淋巴细胞产生IL-2活性降低

似与B细胞产生抗HBS的能力不平行

Abstract

In this report

using anti-HBs reverse plaque forming cell assay

the ability of B cells to produce anti-HBs in vitro was measured on 43 cases of various type of viral hepatitis B infections and 20 cases of HBsAg vacnnees. A marked decrease of anti-HBs synthesis of B cells from the patients with HBV infections was observed in comparison with HBsAg vacci-nees

however

B cells from patients with fulminant hepatic failure showed strong ability to synthesis anti-HBs. A cross coculture experiment using T and B cells suggests that the low ability of B cells to produce anti-HBs in chronic HBsAg carriers be resulted from both their B cells defect and intense suppressor T cell activity. No correlation was observed between low IL-2 activity from lymphocytes and anti-HBs synthesis from B cells of HBV infections

关键词

乙肝表面抗体白细胞间素Ⅱ

Keywords

Anti-HBsIL-2

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