暴发性肝衰竭大鼠模型的体感诱发电位变化

董为伟; 鲁秀容; 陶小红; 钮振; 李宗明

doi:10.13406/j.cnki.cyxb.1988.02.010

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暴发性肝衰竭大鼠模型的体感诱发电位变化

更新时间：2024-01-17

- 暴发性肝衰竭大鼠模型的体感诱发电位变化
- SOMATOSENSORY EVOKED POTENTIALS IN EXPERIMENTAL FULMINANT HEPATIC FAILURE IN RAT
- 重庆医科大学学报 1988年第2期页码：118-122
- 作者机构：
  
  1. 重庆医科大学第一医院神经科
  2. 重庆医科大学人工肝研究室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1988.02.010
  中图分类号：
- 纸质出版日期：1988，
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[1]董为伟,鲁秀容,陶小红,钮振,李宗明.暴发性肝衰竭大鼠模型的体感诱发电位变化[J].重庆医科大学学报,1988(02):118-122.

SOMATOSENSORY EVOKED POTENTIALS IN EXPERIMENTAL FULMINANT HEPATIC FAILURE IN RAT[J]. Journal of Chongqing Medical University, 1988,(2):118-122.
[1]董为伟,鲁秀容,陶小红,钮振,李宗明.暴发性肝衰竭大鼠模型的体感诱发电位变化[J].重庆医科大学学报,1988(02):118-122. DOI： 10.13406/j.cnki.cyxb.1988.02.010.

SOMATOSENSORY EVOKED POTENTIALS IN EXPERIMENTAL FULMINANT HEPATIC FAILURE IN RAT[J]. Journal of Chongqing Medical University, 1988,(2):118-122. DOI： 10.13406/j.cnki.cyxb.1988.02.010.

摘要

本文介绍在GaNl所致FHF大鼠模型检测SEP

观察肝损害进程中SEP

的动态变化.结果发现注射GalN后24小时N

与N

-N

显著缩短;48小时后N

、P

、N

、P

、N

-N

与N

-P

显著延长.说明N

潜伏期延长可供评价HE的指标

Abstract

Somatosensory evoked potentials (SEPs) were recorded in rat model of fulminant hepatic failure induced by galactosamine (GalN)

and the dynamic changes during the process were observed. After stimulating median nerve

4 positive peaks and 4 negative peaks

sequentially designated as I

N3 and P3 could be recorded from the scalp of rat over the contralateral sensory cortex within 80 ms. There were marked shortening of N3 aqd N1-N3 at 24 hour after GalN injection

and marked prolongation of N1

N1-N2 and N1-P2 at 48 hour after GalN injection. Statistical analysis denotes that prolongation of N2 latency is a marker for assessment of experimental hepatic enceph-alopathy and may be of value in clinical diagnosis.

关键词

暴发性肝衰竭体感诱发电位

Keywords

Fulminant hepatic failureSomatosensory evoked potentials

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