小鼠可移植性肝癌（H615）与骨髓瘤细胞（NSl）染色体核型分析

汤为学; 范维珂; 余懋棠

doi:10.13406/j.cnki.cyxb.1986.04.002

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小鼠可移植性肝癌（H615）与骨髓瘤细胞（NSl）染色体核型分析

更新时间：2024-01-17

- 小鼠可移植性肝癌（H615）与骨髓瘤细胞（NSl）染色体核型分析
- CHROMOSOME KARYOTYPE OF THE TRANSPLANTABLE HEPATOCELLULAR CARCINOMA IN MICE(615) AND THE MYELOMA CELL(NSI)
- 重庆医科大学学报 1986年第4期页码：233-236
- 作者机构：
  
  重庆医科大学病理生理教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1986.04.002
  中图分类号：
- 纸质出版日期：1986，
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[1]汤为学,范维珂,余懋棠.小鼠可移植性肝癌(H615)与骨髓瘤细胞(NSl)染色体核型分析[J].重庆医科大学学报,1986(04):233-236+295-296.

CHROMOSOME KARYOTYPE OF THE TRANSPLANTABLE HEPATOCELLULAR CARCINOMA IN MICE(615) AND THE MYELOMA CELL(NSI)[J]. Journal of Chongqing Medical University, 1986,(4):233-236.
[1]汤为学,范维珂,余懋棠.小鼠可移植性肝癌(H615)与骨髓瘤细胞(NSl)染色体核型分析[J].重庆医科大学学报,1986(04):233-236+295-296. DOI： 10.13406/j.cnki.cyxb.1986.04.002.

CHROMOSOME KARYOTYPE OF THE TRANSPLANTABLE HEPATOCELLULAR CARCINOMA IN MICE(615) AND THE MYELOMA CELL(NSI)[J]. Journal of Chongqing Medical University, 1986,(4):233-236. DOI： 10.13406/j.cnki.cyxb.1986.04.002.

摘要

H615瘤细胞含有正常数量的染色体

其众数为40

G、C显带均未见其结构异常。NSI体外培养细胞株染色体众数为65

有二种标记染色体

即中部着丝点染色体及微小染色体。中部着丝点标记染色体在G、C显带时均能证实是由二条端部着丝点染色体融合而成

Abstract

H615 is the first animal model of mouse hepatocellular carcinoma reported in China. H615 cancer cells contain a normal number of 40 chromosomes without abnormal construction as shown ia G and C banding. So

it is inferred that the changes of genetic material may be present only in subband or gene level. NSl cell line is commonly used as fusion partner in hybridoma technology. The chromosomes of NSl cells were analysed for the study of hybridomas. The mean chromosome number is 65 with a metacentric marker chromosome and 1-3 minute chromosomes. It was observed that the centric zone of the ma-ker chromosome had a thicker deep band in G banding and two tele-centric fusion in C banding

关键词

染色体标记细胞培养染色体众数

Keywords

Model chromosome numberChromosomeMarkerCell culture

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