The disposition and pharmacokinetic characteristics of 3H-piperzine ferulate (3H-PF) were studied in present paper.3H-PF absorbed during 2h were 35.4% in stomach and 58.2% in intestine.The blood concentration-time curves obtained from 3H-PF given iv

im and po were adquat-ely fitted by an open two-compartment model. The t=6.8(iv)

19.2(im) and 29.0(po) min; t=47.2min(iv)

1.97(im) and 5.5h(po); Tm=19(im) and 30(po)min. The protein binding% = 38.5(iv) and 31.3(po).When injected iv

the drug was found in higher concentration in liver

kidneys

lungs and blood. After oral administration

higher contents were also found in stomach

intestion and fats in addition to above organs and tissues. The drug could penetrate placenta barrier and distribute into amniotic fluid

placenta and foetus.The excretion rates in 24h were 29.0g6(iv)

18.4%(po)in urine and 14.?9fe(iv)

7.9%(po) in feaces. 33.8% of the iv dose was excreted in the bile during a period of 12h

and there was only 11.4% presented in the feaces. The result indicated that a higher proportion is reabsorbed through hepato-intestnial circulation