骨基质明胶和脱钙骨基质的骨诱导能力及其差异的实验研究

胡晓波

doi:10.13406/j.cnki.cyxb.1986.02.001

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骨基质明胶和脱钙骨基质的骨诱导能力及其差异的实验研究

更新时间：2024-01-17

- 骨基质明胶和脱钙骨基质的骨诱导能力及其差异的实验研究
- EXPERIMENTAL RESEARCH OF BONE INDUCIBLE CAPACITY AND DIFFERENCE OF BONE MATRIX GELATIN AND DECALFIED BONE MATRIX
- 重庆医科大学学报 1986年第2期页码：69-73
- 作者机构：
  
  重庆医科大学第一医院骨科研究生
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1986.02.001
  中图分类号：
- 纸质出版日期：1986，
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[1]胡晓波.骨基质明胶和脱钙骨基质的骨诱导能力及其差异的实验研究[J].重庆医科大学学报,1986(02):69-73+145-146.

First Hospital. EXPERIMENTAL RESEARCH OF BONE INDUCIBLE CAPACITY AND DIFFERENCE OF BONE MATRIX GELATIN AND DECALFIED BONE MATRIX[J]. Journal of Chongqing Medical University, 1986,(2):69-73.
[1]胡晓波.骨基质明胶和脱钙骨基质的骨诱导能力及其差异的实验研究[J].重庆医科大学学报,1986(02):69-73+145-146. DOI： 10.13406/j.cnki.cyxb.1986.02.001.

First Hospital. EXPERIMENTAL RESEARCH OF BONE INDUCIBLE CAPACITY AND DIFFERENCE OF BONE MATRIX GELATIN AND DECALFIED BONE MATRIX[J]. Journal of Chongqing Medical University, 1986,(2):69-73. DOI： 10.13406/j.cnki.cyxb.1986.02.001.

摘要

本文报告一组促进骨折愈合的实验结果

所用试验材料为骨基质明胶片、脱钙骨片和不脱钙骨片。在大鼠颅顶骨上制成8mm直径的圆形骨缺损

作为骨折不连接的动物模型。在此骨缺损内分别植入上述三种材料。结果表明它们都有不同程度的骨诱导作用

其中骨基质明胶片的骨诱导作用最强

脱钙骨片次之。病理组织学观察显示植入片在吸收的同时释放出骨形成性蛋白

诱发来源于硬脑膜的间充质细胞分化为成骨细胞

形成新生骨组织

修复骨缺损

Abstract

Using decalcified bone matrix (DBM)

bone matrix gelatin (BMG) and Undecalcified bone matrix(UDBM)

the capacity of bone induction -was investigated respectively.the experiments were done on the adult rat skulls on which trephine defects of 8 mm in diameter were made

the implants were in form of discs of same size as the defects. BMG was found having the best bone induction capacity

while DBM the next

from the histo-pathological observation

it was suggested that during the process of resorption of BMG and DBM

bone morphogenetic Protein (BMP) was released by diffusion

which induced mesenchymal cells originating from the dura mater to differentiate into osteoblasts and form new bone repairing the bone defects

关键词

细胞分化骨生成非胶原性蛋白质

Keywords

cell differentiationOsteogenesisnencollagenous protein

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