姜黄抗心肌缺血作用及毒性的研究

何高琴; 薛春生

doi:10.13406/j.cnki.cyxb.1986.01.006

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姜黄抗心肌缺血作用及毒性的研究

更新时间：2024-01-17

- 姜黄抗心肌缺血作用及毒性的研究
- STUDIES ON THE MYOCARDIAL ANTIISCHEMIC ACTION AND THE TOXICITY OF CURCUMA LONGA RHIZOME
- 重庆医科大学学报 1986年第1期页码：14-17
- 作者机构：
  
  重庆医科大学药理教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1986.01.006
  中图分类号：
- 纸质出版日期：1986，
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[1]何高琴,薛春生.姜黄抗心肌缺血作用及毒性的研究[J].重庆医科大学学报,1986(01):14-17+70.

STUDIES ON THE MYOCARDIAL ANTIISCHEMIC ACTION AND THE TOXICITY OF CURCUMA LONGA RHIZOME[J]. Journal of Chongqing Medical University, 1986,(1):14-17.
[1]何高琴,薛春生.姜黄抗心肌缺血作用及毒性的研究[J].重庆医科大学学报,1986(01):14-17+70. DOI： 10.13406/j.cnki.cyxb.1986.01.006.

STUDIES ON THE MYOCARDIAL ANTIISCHEMIC ACTION AND THE TOXICITY OF CURCUMA LONGA RHIZOME[J]. Journal of Chongqing Medical University, 1986,(1):14-17. DOI： 10.13406/j.cnki.cyxb.1986.01.006.

摘要

本文研究了姜黄对兔和大鼠实验性心肌缺血和对离体兔心灌流量的影响

姜黄的主要有效成份姜黄素对营养性心肌血流量的影响和毒性试验。结果表明

姜黄对兔和大鼠实验性心肌缺血有保护作用

对离体兔心有直接扩张冠脉、显著增加冠脉流量的作用

姜黄素有显著增加营养性心肌血流量的作用

Abstract

The protective effect of Curcuma Longa Rhizome (CLR) on ischemic myocardium was studied in rats and rabbits. The electrocardiographic pattern of ischemic myocardium induced by pituitrin 0.4 iv

was effectively protected by CLR fluidextract (p<0.01). In isolated rabbit heart

the coronary arterial spasm induced by pituitrin 0.4

could be effectively antagonized by CLR fluidextract

and the coronary outflow was dramatically increased. It was found by means of 86Rb method

that there was a significant increase in nutritional blood flow in myocardium of mice in respo nse to curcumin (active principle of CLR).The acute toxicity of CLR is rather low. In the subacute toxicity study

There was no significant histopathological change to be found in the heart

liver

kidney

aorta

brain

and adrenal glands.Our data suggest that the CLR and its active principle may be useful for preventing and treatment of angina pectoris

关键词

姜黄姜黄素姜黄流浸膏心肌营养血流量

Keywords

Curcuma Longa RhizomecurcuminCurcuma Longa Rhizome fluidextractNutritional blood flow

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