Objective:

2

To examine the effects of hydroxychloroquine（HCQ） treatment on pregnancy outcomes in women with connective tissue disease（CTD）.

Methods:

2

We conducted a retrospective cohort study of pregnant women with CTD in 6 hospitals in recent 10 years（from January 1，2010 to October 30，2020），taking the medical records of Chongqing Medical University Medical Data Scinece Acadmy. A total of 227 patients were included in the study，and classified into two groups according to whether they started HCQ treatment during or six months prior to pregnancy，HCQ treatment group（

n

=108） and control group（

n

=119）.

Results:

2

Compared with the patients in the HCQ treatment group，we found that patients in the control group were more likely to have gestational hypertension（5.0% vs. 17.6%，

P

=0.003），preterm birth（19.3% vs. 25.0%，

P

=0.303），and low birth weight infant（20.0% vs. 45.0%，

P

<

0.001）. Multivariate analysis showed that HCQ treatment was associated with an exceedingly lower risk of gestational hypertension（

OR

=0.31，95%CI=0.10-0.93，

P

=0.037），preterm birth（

OR

=0.28，95%CI=0.10-0.79，

P

=0.016） and low birth weight infant（

OR

=0.31，95%CI=0.13-0.72，

P

=0.006） after controlling for important confounding variables.

Conclusion:

2

Our study proved that HCQ treatment can significantly improve the pregnancy outcomes of patients with CTD，especially reduce the risk of gestational hypertension，preterm birth and low birth weight infant.