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增龄性神经系统改变对认知功能减退的作用机制研究进展
Progress of the mechanism of aging patterns neurological changes on cognitive decline
- 重庆医科大学学报 2021年46卷第11期 页码：1399-1404
- 作者机构：
1.重庆大学附属三峡医院老年科，重庆 404000
2.重庆医科大学附属第一医院老年科，重庆 400016
- 作者简介：
[ "幸奠霞，Email：2020440009@stu.cqums.edu.cn，研究方向：痴呆的基础及临床研究。" ]
吕洋，博士、教授/主任医师、博导，重庆医科大学附属第一医院老年病科副主任。中华医学会老年医学分会青年委员、中华医学会肠外肠内营养学分会青年委员、中华预防医学会老年病预防专委会委员、中华医学会老年医学专委会老年神经病学组委员、中国医师协会神经内科医师分会认知障碍疾病专业委员会委员、中华医学会神经病学专委会神经遗传学组委员、中国老年保健医学研究会抗衰老研究分会常委、中国老年医学学会认知障碍分会（ACDC）常委、中国康复医学会阿尔茨海默病与认知康复专委会常委、中国老年学和老年医学学会脑认知与健康分会常委、重庆市老年痴呆防治协会会长、重庆市医学会老年医学分会副主任委员、重庆市医师协会老年医学科医师分会副会长、重庆市老年学和老年医学学会副会长/老年保健康复分会主任委员；主持国家自然科学基金在内的各级项目29项；以第一完成人获得重庆市科技进步二等奖2项、国家发明专利2项；以第一作者或通信作者发表SCI期刊收录论文37篇。Email：yanglyu@hospital.cqmu.edu.cn。
- 基金信息：重庆市基础研究与前沿探索资助项目(编号：cstc2018jcyjAX0169)
DOI：10.13406/j.cnki.cyxb.002926
中图分类号： R749.16纸质出版日期：2021-11-28，
收稿日期：2021-07-05，
扫 描 看 全 文
幸奠霞, 吕洋. 增龄性神经系统改变对认知功能减退的作用机制研究进展[J]. 重庆医科大学学报, 2021,46(11):1399-1404.
Dianxia Xing, Yang Lü. Progress of the mechanism of aging patterns neurological changes on cognitive decline[J]. Journal of Shanxi Agricultural Sciences, 2021,46(11):1399-1404.
幸奠霞, 吕洋. 增龄性神经系统改变对认知功能减退的作用机制研究进展[J]. 重庆医科大学学报, 2021,46(11):1399-1404. DOI： 10.13406/j.cnki.cyxb.002926.
Dianxia Xing, Yang Lü. Progress of the mechanism of aging patterns neurological changes on cognitive decline[J]. Journal of Shanxi Agricultural Sciences, 2021,46(11):1399-1404. DOI： 10.13406/j.cnki.cyxb.002926.
摘要
增龄导致的认知功能减退可造成巨大的家庭社会负担，其发病机制在近年来得到广泛研究。本文就增龄过程中神经系统代谢改变、神经元、胶质细胞、神经干细胞衰老及血脑屏障相关成分改变对认知功能的影响机制展开综述。
Abstract
The cognitive decline caused by aging can cause a heavy social burden
and its pathogenesis has been studied widely in recent years. In this paper
we review the metabolism of the nervous system
aging of neurons
glial cells
neural stem cells
changes of components related to the blood-brain barrier
and their effects on cognitive function during aging.
关键词
增龄认知功能减退神经系统改变机制进展
Keywords
agingcognitive declineneurological changesmechanismprogress
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