认知正常与轻度认知障碍老年人海马亚区与序列位置效应关系的研究

冀琳娜; 黄娟; 文潇; 秦玮婷; 李放

doi:10.13406/j.cnki.cyxb.002925

您当前的位置：

首页 >

文章列表页 >

认知正常与轻度认知障碍老年人海马亚区与序列位置效应关系的研究

认知障碍与中枢生物标志物关系研究 | 更新时间：2022-06-24

- 认知正常与轻度认知障碍老年人海马亚区与序列位置效应关系的研究
- Association of hippocampal subfields and serial position effect in the elderly with normal cognition and mild cognitive impairment
- 重庆医科大学学报 2021年46卷第11期页码：1376-1381
- 作者机构：
  
  首都医科大学附属复兴医院神经内科，北京　100038
- 作者简介：
  
  [ "冀琳娜，Email：jilinnaa@163.com，研究方向：认知障碍。" ]
  李放，博士、主任医师、副教授、硕导，首都医科大学附属复兴医院神经内一科主任。首都医科大学神经病学系委员、中国老年学学会心脑血管病专业委员会委员、中国老年保健医学研究会抗衰老研究分会委员、中国老年保健医学研究会老年合理用药分会青年委员会委员、北京中西医结合学会核医学专业委员、北京医学会老年病学分会青年委员会委员；以第一作者或通信作者发表中英文文章11篇。Email：li_fang@ccmu.edu.cn。
- 基金信息：
  
  北京市保健课题资助项目(京19-5)
- DOI：10.13406/j.cnki.cyxb.002925
  中图分类号： R741
- 纸质出版日期：2021-11-28，
  
  收稿日期：2021-07-04，
扫描看全文
冀琳娜, 黄娟, 文潇, 等. 认知正常与轻度认知障碍老年人海马亚区与序列位置效应关系的研究[J]. 重庆医科大学学报, 2021,46(11):1376-1381.

Linna Ji, Juan Huang, Xiao Wen, et al. Association of hippocampal subfields and serial position effect in the elderly with normal cognition and mild cognitive impairment[J]. Journal of Shanxi Agricultural Sciences, 2021,46(11):1376-1381.
冀琳娜, 黄娟, 文潇, 等. 认知正常与轻度认知障碍老年人海马亚区与序列位置效应关系的研究[J]. 重庆医科大学学报, 2021,46(11):1376-1381. DOI： 10.13406/j.cnki.cyxb.002925.

Linna Ji, Juan Huang, Xiao Wen, et al. Association of hippocampal subfields and serial position effect in the elderly with normal cognition and mild cognitive impairment[J]. Journal of Shanxi Agricultural Sciences, 2021,46(11):1376-1381. DOI： 10.13406/j.cnki.cyxb.002925.

摘要

目的：

研究认知正常与轻度认知障碍老年人海马亚区与序列位置效应的相关性。

方法：

选择2016年1月至2019年1月就诊于首都医科大学附属复兴医院神经内科门诊的21例轻度认知障碍（mild cognitive impairment，MCI）患者作为MCI组，同期选择体检中心及门诊的39位认知正常（normal cognition，NC）者作为对照组。所有受试者均进行成套神经心理学量表评估与头颅核磁共振检查。应用自动化海马亚区分割软件FreeSurfer计算各亚区体积，采用听觉词语学习测验（auditory verbal learning test，AVLT）记录序列位置效应结果，观察2组人群亚区体积的差异，并分析其与序列位置效应的相关性。

结果：

MCI组患者海马各亚区体积均小于对照组，但经多重比较的Bonferroni校正后，仅前下托区差异有统计学意义（

0.05）。该亚区与AVLT延迟回忆总分及首因分数呈正相关。

结论：

与对照组相比，MCI患者海马亚区体积减少，其中前下托萎缩更显著，与长时记忆损害相关。

Abstract

Objective

To explore the correlation between the hippocampal subfields and serial position effect in the elderly with normal cognition and mild cognitive impairment.

Methods

A total of 21 subjects with mild cognitive impairment (MCI) treated in Fu Xing Hospital

Capital Medical University from January 2016 to January 2019 were selected as the MCI group

and 39 healthy controls (HC) with normal cognition (NC) from physical examination center and outpatient department were simultaneously selected as control group. All participants completed a set of neuropsychological assessment and were all examined by head MRI. The score of serial position effect was obtained using the auditory verbal learning test (AVLT). T1-weighted structural MRI data were collected after cognitive testing

and the subfields of the hippocampal formation were segmented automatically using the FreeSurfer 6.0 software

then volumetric estimates and estimated total intracranial volume were also calculated. Finally

the relationship between hippocampal subfields and serial position effect were analyzed.

Results

The volume of each hippocampal subfield of MCI was smaller than that of the healthy control

but after Bonferroni correction of multiple comparison

only the difference in the presubiculum was statistically significant (

0.05). The presubiculum was positively correlated with the total score of AVLT delayed recall and the score of primacy effect.

Conclusion

Compared with the healthy control

the MCI patients show atrophy in all subfields. The volume of the presubiculum presents the most prominent reduction

which is correlated with the impairment of long-term memory.

关键词

海马亚区序列位置效应轻度认知障碍

Keywords

hippocampal subfieldserial position effectmild cognitive impairment

references

Maruszak A, Thuret S. Why looking at the whole Hippocampus is not enough—a critical role for anteroposterior axis, subfield and activation analyses to enhance predictive value of hippocampal changes for Alzheimer's disease diagnosis[J]. Front Cell Neurosci, 2014, 8:95.

de Flores R, La Joie R, Chételat G. Structural imaging of hippocampal subfields in healthy aging and Alzheimer's disease[J]. Neuroscience, 2015, 309:29-50.

2021 Alzheimer's disease facts and figures[J]. Alzheimers Dement, 2021, 17(3):327-406.

李沁洁, 苗雅, 钟远. 华山版听觉词语学习测验在遗忘型轻度认知障碍诊断中的应用[J]. 老年医学与保健, 2016, 22(5):282-285.

Gicas KM, Honer WG, Wilson RS, et al. Association of serial position scores on memory tests and hippocampal-related neuropathologic outcomes[J]. Neurology, 2020, 95(24):e3303-e3312.

Weitzner DS, Calamia M. Serial position effects on list learning tasks in mild cognitive impairment and Alzheimer's disease[J]. Neuropsychology, 2020, 34(4):467-478.

Turchetta CS, de Simone MS, Perri R, et al. Forgetting rates on the recency portion of a word list predict conversion from mild cognitive impairment to Alzheimer's disease[J]. J Alzheimers Dis, 2020, 73(4):1295-1304.

Atkinson RC, Shiffrin RM. Human memory: a proposed system and its control processes[J]. Psychol Learn Motiv, 1968, 2:89-195.

Petersen RC, Smith GE, Waring SC, et al. Mild cognitive impairment: clinical characterization and outcome[J]. Arch Neurol, 1999, 56(3):303-308.

Carlesimo GA, Piras F, Orfei MD, et al. Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease[J]. Alzheimers Dement(Amst), 2015, 1(1):24-32.

West MJ, Coleman PD, Flood DG, et al. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease[J]. Lancet, 1994, 344(8925):769-772.

West MJ, Kawas CH, Stewart WF, et al. Hippocampal neurons in pre-clinical Alzheimer's disease[J]. Neurobiol Aging, 2004, 25(9):1205-1212.

Rössler M, Zarski R, Bohl J, et al. Stage-dependent and sectorspecific neuronal loss in Hippocampus during Alzheimer's disease[J]. Acta Neuropathol, 2002, 103(4):363-369.

Parker TD, Cash DM, Lane CAS, et al. Hippocampal subfield volumes and pre-clinical Alzheimer's disease in 408 cognitively normal adults born in 1946[J]. PLoS One, 2019, 14(10):e0224030.

Jacobs HIL, Augustinack JC, Schultz AP, et al. The presubiculum links incipient amyloid and tau pathology to memory function in older persons[J]. Neurology, 2020, 94(18):e1916-e1928.

Foo H, Mak E, Chander RJ, et al. Associations of hippocampal subfields in the progression of cognitive decline related to Parkinson's disease[J]. Neuroimage Clin, 2017, 14:37-42.

罗财妹, 李梦春, 秦若梦, 等. 阿尔茨海默病谱系患者的海马亚区体积损害特征[J]. 中风与神经疾病杂志, 2019, 36(12):1097-1101.

Zhao WN, Wang XT, Yin CH, et al. Trajectories of the hippocampal subfields atrophy in the Alzheimer's disease: a structural imaging study[J]. Front Neuroinform, 2019, 13:13.

Zheng FL, Cui D, Zhang L, et al. The volume of hippocampal subfields in relation to decline of memory recall across the adult lifespan[J]. Front Aging Neurosci, 2018, 10:320.

黄娟, 李放, 方向华, 等. 序列位置效应联合延迟回忆识别不同认知障碍水平患者的研究[J]. 中华老年医学杂志, 2021, 40(2):158-162.

Amani M, Lauterborn JC, Le AA, et al. Rapid aging in the perforant path projections to the rodent dentate gyrus[J]. J Neurosci, 2021, 41(10):2301-2312.

Huo LJ, Li R, Wang PY, et al. The default mode network supports episodic memory in cognitively unimpaired elderly individuals: different contributions to immediate recall and delayed recall[J]. Front Aging Neurosci, 2018, 10:6.

Joshi H, Bharath S, John JP, et al. Resting state functional connectivity abnormalities and delayed recall performance in patients with amnestic mild cognitive impairment[J]. Brain Imaging Behav, 2020, 14(1):267-277.

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

教育与载脂蛋白E基因交互作用调节轻度认知障碍患者的认知功能和脑网络活性

基于全脑影像组学的阿尔茨海默病诊断研究

蒙特利尔认知评估量表测量不同教育水平轻度认知障碍的适用性研究