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海马亚区在阿尔茨海默病中的研究进展
Advances in the study of hippocampal subregion in Alzheimer's disease
- 重庆医科大学学报 2021年46卷第11期 页码：1391-1394
- 作者机构：
吉林大学中日联谊医院南湖神经内科、吉林省记忆与认知障碍疾病工程实验室，长春 130000
- 作者简介：
[ "吕书悦，Email：2312865219@qq.com，研究方向：阿尔茨海默病。" ]
赵晴，博士、主任医师、博导，吉林大学中日联谊医院南湖神经内科主任。吉林省医学会神经病学专业委员会常委、痴呆及认知障碍学组副组长，中国老年医学会认知及心理障碍分会委员（ACDC），中国微循环学会神经变性病专业委员会委员、东北分会常委，中国卒中学会血管性认知障碍学组委员，国际阿尔茨海默病防治协会首届神经认知分会委员，中国中药协会脑病药物研究专业委员会常委，中国老年学和老年医学会脑认知与健康分会常委，吉林省医师协会神经病学分会委员、运动障碍学组常委，吉林省卒中学会老年病学组委员，中国全科医学杂志及中国组织工程学杂志外审专家。现承担部省级课题10项，可支配经费400万元。发表论文50余篇，其中SCI论文20篇，核心期刊论文30余篇，编著1部。获吉林大学医疗成果奖4项。Email：zhaoqing@jlu.edu.cn
- 基金信息：吉林省科技发展计划项目(20200404076YY);吉林省记忆与认知障碍疾病工程实验室(2020C054)
DOI：10.13406/j.cnki.cyxb.002923
中图分类号： R741纸质出版日期：2021-11-28，
收稿日期：2021-07-31，
扫 描 看 全 文
吕书悦, 孙文悦, 吴凡, 等. 海马亚区在阿尔茨海默病中的研究进展[J]. 重庆医科大学学报, 2021,46(11):1391-1394.
Shuyue Lü, Wenyue Sun, Fan Wu, et al. Advances in the study of hippocampal subregion in Alzheimer's disease[J]. Journal of Shanxi Agricultural Sciences, 2021,46(11):1391-1394.
吕书悦, 孙文悦, 吴凡, 等. 海马亚区在阿尔茨海默病中的研究进展[J]. 重庆医科大学学报, 2021,46(11):1391-1394. DOI： 10.13406/j.cnki.cyxb.002923.
Shuyue Lü, Wenyue Sun, Fan Wu, et al. Advances in the study of hippocampal subregion in Alzheimer's disease[J]. Journal of Shanxi Agricultural Sciences, 2021,46(11):1391-1394. DOI： 10.13406/j.cnki.cyxb.002923.
摘要
阿尔茨海默病（Alzheimer's disease，AD）是一种进行性的神经系统退行性疾病。海马是AD发病过程中最早且特异性较高的一种标志物，分为CA1~4亚区。海马亚区涉及情景记忆、社会记忆、联想记忆的处理，其改变与衰老、Aβ沉积、tau蛋白过度磷酸化、缺血等影响因素相关。研究海马亚区与AD的相关性，对AD的早期识别及诊断具有重要临床意义，可能为AD的治疗提供新的思路。
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disease. The hippocampus is the earliest and highly specific marker in the pathogenesis of AD
which can be divided into CA1-4 subregions. The hippocampal subregion is involved in the processing of episodic memory
social memory and associative memory
and is associated with aging
Aβ deposition
hyperphosphorylation of tau protein
ischemia and other influencing factors. The study of the changes in the hippocampal subregion in AD is of great clinical significance for the early identification and diagnosis of AD
and may provide new ideas for the treatment of AD.
关键词
阿尔茨海默病海马海马亚区认知功能
Keywords
Alzheimer's diseasehippocampushippocampal subregioncognitive function
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